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Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease

Diet and nutritional status affect intestinal inflammation in patients with inflammatory bowel disease (IBD). The aim of this study was to use a cluster analysis to assess structural similarity between different groups of parameters including short-chain fatty acid (SCFA) levels in stool as well as...

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Autores principales: Dąbek-Drobny, Agnieszka, Kaczmarczyk, Olga, Piątek-Guziewicz, Agnieszka, Woźniakiewicz, Michał, Paśko, Paweł, Dobrowolska-Iwanek, Justyna, Woźniakiewicz, Aneta, Targosz, Aneta, Ptak-Belowska, Agata, Zagrodzki, Paweł, Zwolińska-Wcisło, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572297/
https://www.ncbi.nlm.nih.gov/pubmed/36235613
http://dx.doi.org/10.3390/nu14193960
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author Dąbek-Drobny, Agnieszka
Kaczmarczyk, Olga
Piątek-Guziewicz, Agnieszka
Woźniakiewicz, Michał
Paśko, Paweł
Dobrowolska-Iwanek, Justyna
Woźniakiewicz, Aneta
Targosz, Aneta
Ptak-Belowska, Agata
Zagrodzki, Paweł
Zwolińska-Wcisło, Małgorzata
author_facet Dąbek-Drobny, Agnieszka
Kaczmarczyk, Olga
Piątek-Guziewicz, Agnieszka
Woźniakiewicz, Michał
Paśko, Paweł
Dobrowolska-Iwanek, Justyna
Woźniakiewicz, Aneta
Targosz, Aneta
Ptak-Belowska, Agata
Zagrodzki, Paweł
Zwolińska-Wcisło, Małgorzata
author_sort Dąbek-Drobny, Agnieszka
collection PubMed
description Diet and nutritional status affect intestinal inflammation in patients with inflammatory bowel disease (IBD). The aim of this study was to use a cluster analysis to assess structural similarity between different groups of parameters including short-chain fatty acid (SCFA) levels in stool as well as hematological and inflammatory parameters (such as serum C-reactive protein (CRP) and proinflammatory and anti-inflammatory cytokines). We also assessed similarity between IBD patients in terms of various biochemical features of disease activity and nutritional status. A total of 48 participants were enrolled, including 36 patients with IBD and 12 controls. We identified four main meaningful clusters of parameters. The first cluster included all SCFAs with strong mutual correlations. The second cluster contained red blood cell parameters and albumin levels. The third cluster included proinflammatory parameters such as tumor necrosis factor-α, CRP, platelets, and phosphoric, succinic, and lactic acids. The final cluster revealed an association between zonulin and interleukins IL-10, IL-17, and IL-22. Moreover, we observed an inverse correlation between IL-6 and body mass index. Our findings suggest a link between nutritional status, diet, and inflammatory parameters in patients with IBD, which contribute to a better adjustment of the nutritional treatment.
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spelling pubmed-95722972022-10-17 Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease Dąbek-Drobny, Agnieszka Kaczmarczyk, Olga Piątek-Guziewicz, Agnieszka Woźniakiewicz, Michał Paśko, Paweł Dobrowolska-Iwanek, Justyna Woźniakiewicz, Aneta Targosz, Aneta Ptak-Belowska, Agata Zagrodzki, Paweł Zwolińska-Wcisło, Małgorzata Nutrients Article Diet and nutritional status affect intestinal inflammation in patients with inflammatory bowel disease (IBD). The aim of this study was to use a cluster analysis to assess structural similarity between different groups of parameters including short-chain fatty acid (SCFA) levels in stool as well as hematological and inflammatory parameters (such as serum C-reactive protein (CRP) and proinflammatory and anti-inflammatory cytokines). We also assessed similarity between IBD patients in terms of various biochemical features of disease activity and nutritional status. A total of 48 participants were enrolled, including 36 patients with IBD and 12 controls. We identified four main meaningful clusters of parameters. The first cluster included all SCFAs with strong mutual correlations. The second cluster contained red blood cell parameters and albumin levels. The third cluster included proinflammatory parameters such as tumor necrosis factor-α, CRP, platelets, and phosphoric, succinic, and lactic acids. The final cluster revealed an association between zonulin and interleukins IL-10, IL-17, and IL-22. Moreover, we observed an inverse correlation between IL-6 and body mass index. Our findings suggest a link between nutritional status, diet, and inflammatory parameters in patients with IBD, which contribute to a better adjustment of the nutritional treatment. MDPI 2022-09-23 /pmc/articles/PMC9572297/ /pubmed/36235613 http://dx.doi.org/10.3390/nu14193960 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dąbek-Drobny, Agnieszka
Kaczmarczyk, Olga
Piątek-Guziewicz, Agnieszka
Woźniakiewicz, Michał
Paśko, Paweł
Dobrowolska-Iwanek, Justyna
Woźniakiewicz, Aneta
Targosz, Aneta
Ptak-Belowska, Agata
Zagrodzki, Paweł
Zwolińska-Wcisło, Małgorzata
Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease
title Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease
title_full Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease
title_fullStr Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease
title_full_unstemmed Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease
title_short Application of the Clustering Technique to Multiple Nutritional Factors Related to Inflammation and Disease Progression in Patients with Inflammatory Bowel Disease
title_sort application of the clustering technique to multiple nutritional factors related to inflammation and disease progression in patients with inflammatory bowel disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572297/
https://www.ncbi.nlm.nih.gov/pubmed/36235613
http://dx.doi.org/10.3390/nu14193960
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