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Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys

Magnesium alloys are attractive candidates for use as temporary fixation devices in osteosynthesis because they have a density and Young’s modulus similar to those of cortical bone. One of the main requirements for biodegradable implants is its substitution by tissues during the healing process. In...

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Autores principales: Bazhenov, Viacheslav, Li, Anna, Tavolzhanskii, Stanislav, Bazlov, Andrey, Tabachkova, Natalia, Koltygin, Andrey, Komissarov, Alexander, Shin, Kwang Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572374/
https://www.ncbi.nlm.nih.gov/pubmed/36234190
http://dx.doi.org/10.3390/ma15196849
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author Bazhenov, Viacheslav
Li, Anna
Tavolzhanskii, Stanislav
Bazlov, Andrey
Tabachkova, Natalia
Koltygin, Andrey
Komissarov, Alexander
Shin, Kwang Seon
author_facet Bazhenov, Viacheslav
Li, Anna
Tavolzhanskii, Stanislav
Bazlov, Andrey
Tabachkova, Natalia
Koltygin, Andrey
Komissarov, Alexander
Shin, Kwang Seon
author_sort Bazhenov, Viacheslav
collection PubMed
description Magnesium alloys are attractive candidates for use as temporary fixation devices in osteosynthesis because they have a density and Young’s modulus similar to those of cortical bone. One of the main requirements for biodegradable implants is its substitution by tissues during the healing process. In this article, the Mg–Zn–Ga–(Y) alloys were investigated that potentially can increase the bone growth rate by release of Ga ions during the degradation process. Previously, the effectiveness of Ga ions on bone tissue regeneration has been proved by clinical tests. This work is the first systematic study on the microstructure and mechanical properties of Mg–Zn–Y alloys containing Ga as an additional major alloying element prepared by the hot-extrusion process. The microstructure and phase composition of the Mg–Zn–Ga–(Y) alloys in as-cast, heat-treated, and extruded conditions were analyzed. In addition, it was shown that the use of hot extrusion produces Mg–Zn–Ga–(Y) alloys with favorable mechanical properties. The tensile yield strength, ultimate tensile strength, and elongation at fracture of the MgZn4Ga4 alloy extruded at 150 °C were 256 MPa, 343 MPa, and 14.2%, respectively. Overall, MgZn4Ga4 alloy is a perspective for applications in implants for osteosynthesis with improved bone regeneration ability.
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spelling pubmed-95723742022-10-17 Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys Bazhenov, Viacheslav Li, Anna Tavolzhanskii, Stanislav Bazlov, Andrey Tabachkova, Natalia Koltygin, Andrey Komissarov, Alexander Shin, Kwang Seon Materials (Basel) Article Magnesium alloys are attractive candidates for use as temporary fixation devices in osteosynthesis because they have a density and Young’s modulus similar to those of cortical bone. One of the main requirements for biodegradable implants is its substitution by tissues during the healing process. In this article, the Mg–Zn–Ga–(Y) alloys were investigated that potentially can increase the bone growth rate by release of Ga ions during the degradation process. Previously, the effectiveness of Ga ions on bone tissue regeneration has been proved by clinical tests. This work is the first systematic study on the microstructure and mechanical properties of Mg–Zn–Y alloys containing Ga as an additional major alloying element prepared by the hot-extrusion process. The microstructure and phase composition of the Mg–Zn–Ga–(Y) alloys in as-cast, heat-treated, and extruded conditions were analyzed. In addition, it was shown that the use of hot extrusion produces Mg–Zn–Ga–(Y) alloys with favorable mechanical properties. The tensile yield strength, ultimate tensile strength, and elongation at fracture of the MgZn4Ga4 alloy extruded at 150 °C were 256 MPa, 343 MPa, and 14.2%, respectively. Overall, MgZn4Ga4 alloy is a perspective for applications in implants for osteosynthesis with improved bone regeneration ability. MDPI 2022-10-02 /pmc/articles/PMC9572374/ /pubmed/36234190 http://dx.doi.org/10.3390/ma15196849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bazhenov, Viacheslav
Li, Anna
Tavolzhanskii, Stanislav
Bazlov, Andrey
Tabachkova, Natalia
Koltygin, Andrey
Komissarov, Alexander
Shin, Kwang Seon
Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys
title Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys
title_full Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys
title_fullStr Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys
title_full_unstemmed Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys
title_short Microstructure and Mechanical Properties of Hot-Extruded Mg–Zn–Ga–(Y) Biodegradable Alloys
title_sort microstructure and mechanical properties of hot-extruded mg–zn–ga–(y) biodegradable alloys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572374/
https://www.ncbi.nlm.nih.gov/pubmed/36234190
http://dx.doi.org/10.3390/ma15196849
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