Cargando…

Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker

Five new furofurans lignans, Brasesquilignan A–E (1–5), were isolated from the aqueous ethanol extract of Selaginella braunii Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Fei, Wu, Jianping, Zhang, Yan, Wang, Yuyan, Li, Guihua, Zeng, Hongliang, He, Xiaoai, Deng, Guiming, Tan, Jianbin, Long, Hongping, Zeng, Puhua, Liu, Yiheng, Zhu, Gangzhi, Chen, Zuhui, Xu, Kangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572557/
https://www.ncbi.nlm.nih.gov/pubmed/36234885
http://dx.doi.org/10.3390/molecules27196349
_version_ 1784810644936065024
author Cheng, Fei
Wu, Jianping
Zhang, Yan
Wang, Yuyan
Li, Guihua
Zeng, Hongliang
He, Xiaoai
Deng, Guiming
Tan, Jianbin
Long, Hongping
Zeng, Puhua
Liu, Yiheng
Zhu, Gangzhi
Chen, Zuhui
Xu, Kangping
author_facet Cheng, Fei
Wu, Jianping
Zhang, Yan
Wang, Yuyan
Li, Guihua
Zeng, Hongliang
He, Xiaoai
Deng, Guiming
Tan, Jianbin
Long, Hongping
Zeng, Puhua
Liu, Yiheng
Zhu, Gangzhi
Chen, Zuhui
Xu, Kangping
author_sort Cheng, Fei
collection PubMed
description Five new furofurans lignans, Brasesquilignan A–E (1–5), were isolated from the aqueous ethanol extract of Selaginella braunii Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and GCMS analysis. Furthermore, all compounds were evaluated for anti-proliferative activities against various human cancer cellsin vitro. Compounds 2 and 3 exhibited weak inhibitorypotency against five human cancer cells.
format Online
Article
Text
id pubmed-9572557
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95725572022-10-17 Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker Cheng, Fei Wu, Jianping Zhang, Yan Wang, Yuyan Li, Guihua Zeng, Hongliang He, Xiaoai Deng, Guiming Tan, Jianbin Long, Hongping Zeng, Puhua Liu, Yiheng Zhu, Gangzhi Chen, Zuhui Xu, Kangping Molecules Article Five new furofurans lignans, Brasesquilignan A–E (1–5), were isolated from the aqueous ethanol extract of Selaginella braunii Baker. Their structures were elucidated by extensive analysis of NMR and HRESIMS data. Their absolute configurations were determined by CD spectra, enzymatic hydrolysis, and GCMS analysis. Furthermore, all compounds were evaluated for anti-proliferative activities against various human cancer cellsin vitro. Compounds 2 and 3 exhibited weak inhibitorypotency against five human cancer cells. MDPI 2022-09-26 /pmc/articles/PMC9572557/ /pubmed/36234885 http://dx.doi.org/10.3390/molecules27196349 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Fei
Wu, Jianping
Zhang, Yan
Wang, Yuyan
Li, Guihua
Zeng, Hongliang
He, Xiaoai
Deng, Guiming
Tan, Jianbin
Long, Hongping
Zeng, Puhua
Liu, Yiheng
Zhu, Gangzhi
Chen, Zuhui
Xu, Kangping
Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker
title Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker
title_full Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker
title_fullStr Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker
title_full_unstemmed Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker
title_short Brasesquilignan A–E, Five New Furofurans Lignans from Selaginella braunii Baker
title_sort brasesquilignan a–e, five new furofurans lignans from selaginella braunii baker
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572557/
https://www.ncbi.nlm.nih.gov/pubmed/36234885
http://dx.doi.org/10.3390/molecules27196349
work_keys_str_mv AT chengfei brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT wujianping brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT zhangyan brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT wangyuyan brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT liguihua brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT zenghongliang brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT hexiaoai brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT dengguiming brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT tanjianbin brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT longhongping brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT zengpuhua brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT liuyiheng brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT zhugangzhi brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT chenzuhui brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker
AT xukangping brasesquilignanaefivenewfurofuranslignansfromselaginellabrauniibaker