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Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study

Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained...

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Autores principales: Su, Guobin, Saglimbene, Valeria, Wong, Germaine, Bernier-Jean, Amélie, Carrero, Juan Jesus, Natale, Patrizia, Ruospo, Marinella, Hegbrant, Jorgen, Craig, Jonathan C., Strippoli, Giovanni F. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572675/
https://www.ncbi.nlm.nih.gov/pubmed/36235716
http://dx.doi.org/10.3390/nu14194064
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author Su, Guobin
Saglimbene, Valeria
Wong, Germaine
Bernier-Jean, Amélie
Carrero, Juan Jesus
Natale, Patrizia
Ruospo, Marinella
Hegbrant, Jorgen
Craig, Jonathan C.
Strippoli, Giovanni F. M.
author_facet Su, Guobin
Saglimbene, Valeria
Wong, Germaine
Bernier-Jean, Amélie
Carrero, Juan Jesus
Natale, Patrizia
Ruospo, Marinella
Hegbrant, Jorgen
Craig, Jonathan C.
Strippoli, Giovanni F. M.
author_sort Su, Guobin
collection PubMed
description Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality.
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spelling pubmed-95726752022-10-17 Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study Su, Guobin Saglimbene, Valeria Wong, Germaine Bernier-Jean, Amélie Carrero, Juan Jesus Natale, Patrizia Ruospo, Marinella Hegbrant, Jorgen Craig, Jonathan C. Strippoli, Giovanni F. M. Nutrients Article Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality. MDPI 2022-09-30 /pmc/articles/PMC9572675/ /pubmed/36235716 http://dx.doi.org/10.3390/nu14194064 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Guobin
Saglimbene, Valeria
Wong, Germaine
Bernier-Jean, Amélie
Carrero, Juan Jesus
Natale, Patrizia
Ruospo, Marinella
Hegbrant, Jorgen
Craig, Jonathan C.
Strippoli, Giovanni F. M.
Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study
title Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study
title_full Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study
title_fullStr Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study
title_full_unstemmed Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study
title_short Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study
title_sort dietary phosphorus, its sources, and mortality in adults on haemodialysis: the diet-hd study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572675/
https://www.ncbi.nlm.nih.gov/pubmed/36235716
http://dx.doi.org/10.3390/nu14194064
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