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Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study
Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572675/ https://www.ncbi.nlm.nih.gov/pubmed/36235716 http://dx.doi.org/10.3390/nu14194064 |
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author | Su, Guobin Saglimbene, Valeria Wong, Germaine Bernier-Jean, Amélie Carrero, Juan Jesus Natale, Patrizia Ruospo, Marinella Hegbrant, Jorgen Craig, Jonathan C. Strippoli, Giovanni F. M. |
author_facet | Su, Guobin Saglimbene, Valeria Wong, Germaine Bernier-Jean, Amélie Carrero, Juan Jesus Natale, Patrizia Ruospo, Marinella Hegbrant, Jorgen Craig, Jonathan C. Strippoli, Giovanni F. M. |
author_sort | Su, Guobin |
collection | PubMed |
description | Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality. |
format | Online Article Text |
id | pubmed-9572675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95726752022-10-17 Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study Su, Guobin Saglimbene, Valeria Wong, Germaine Bernier-Jean, Amélie Carrero, Juan Jesus Natale, Patrizia Ruospo, Marinella Hegbrant, Jorgen Craig, Jonathan C. Strippoli, Giovanni F. M. Nutrients Article Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality. MDPI 2022-09-30 /pmc/articles/PMC9572675/ /pubmed/36235716 http://dx.doi.org/10.3390/nu14194064 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Su, Guobin Saglimbene, Valeria Wong, Germaine Bernier-Jean, Amélie Carrero, Juan Jesus Natale, Patrizia Ruospo, Marinella Hegbrant, Jorgen Craig, Jonathan C. Strippoli, Giovanni F. M. Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study |
title | Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study |
title_full | Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study |
title_fullStr | Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study |
title_full_unstemmed | Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study |
title_short | Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study |
title_sort | dietary phosphorus, its sources, and mortality in adults on haemodialysis: the diet-hd study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572675/ https://www.ncbi.nlm.nih.gov/pubmed/36235716 http://dx.doi.org/10.3390/nu14194064 |
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