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Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial

Dietary fiber exerts beneficial effects on human health reducing the risk factors of metabolic related diseases such as hyperglycemia, insulin resistance, and hypercholesterolemia. The aim of this study is to demonstrate the efficacy of a food supplement based on brewer’s spent grain (BSG) extract i...

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Autores principales: Ullah, Hammad, Esposito, Cristina, Piccinocchi, Roberto, De Lellis, Lorenza Francesca, Santarcangelo, Cristina, Minno, Alessandro Di, Baldi, Alessandra, Buccato, Daniele Giuseppe, Khan, Ayesha, Piccinocchi, Gaetano, Sacchi, Roberto, Daglia, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572698/
https://www.ncbi.nlm.nih.gov/pubmed/36235569
http://dx.doi.org/10.3390/nu14193916
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author Ullah, Hammad
Esposito, Cristina
Piccinocchi, Roberto
De Lellis, Lorenza Francesca
Santarcangelo, Cristina
Minno, Alessandro Di
Baldi, Alessandra
Buccato, Daniele Giuseppe
Khan, Ayesha
Piccinocchi, Gaetano
Sacchi, Roberto
Daglia, Maria
author_facet Ullah, Hammad
Esposito, Cristina
Piccinocchi, Roberto
De Lellis, Lorenza Francesca
Santarcangelo, Cristina
Minno, Alessandro Di
Baldi, Alessandra
Buccato, Daniele Giuseppe
Khan, Ayesha
Piccinocchi, Gaetano
Sacchi, Roberto
Daglia, Maria
author_sort Ullah, Hammad
collection PubMed
description Dietary fiber exerts beneficial effects on human health reducing the risk factors of metabolic related diseases such as hyperglycemia, insulin resistance, and hypercholesterolemia. The aim of this study is to demonstrate the efficacy of a food supplement based on brewer’s spent grain (BSG) extract in the reduction of postprandial glycemia and insulinemia in normoglycemic subjects. BSG was chemically characterized, revealing the presence of resistant starch (14.64 g/100 g), arabinoxylans (7.50 g/100 g), β-glucans (1.92 g/100 g) and other soluble fibers (6.43 g/100 g), and bioaccessible ferulic acid (91.3 mg/100 g). For the clinical study, 40 normoglycemic subjects were randomized into two groups, 1 and 2 (n = 20), for a cross-over clinical design and received either BSG extract-based food supplement or placebo. Postprandial blood glucose values were significantly lower than corresponding values in the placebo group after 90 and 120 min, while at the baseline and in the first 60 min, the two glycemic curves overlapped substantially. This improved clinical outcome was corroborated by significant reductions in postprandial insulinemia. None of the subjects reported adverse effects. This study showed that the tested BSG extract-based food supplement improves glucose metabolism and insulinemic response in normoglycemic subjects with at most a mild insulin resistance.
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spelling pubmed-95726982022-10-17 Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial Ullah, Hammad Esposito, Cristina Piccinocchi, Roberto De Lellis, Lorenza Francesca Santarcangelo, Cristina Minno, Alessandro Di Baldi, Alessandra Buccato, Daniele Giuseppe Khan, Ayesha Piccinocchi, Gaetano Sacchi, Roberto Daglia, Maria Nutrients Article Dietary fiber exerts beneficial effects on human health reducing the risk factors of metabolic related diseases such as hyperglycemia, insulin resistance, and hypercholesterolemia. The aim of this study is to demonstrate the efficacy of a food supplement based on brewer’s spent grain (BSG) extract in the reduction of postprandial glycemia and insulinemia in normoglycemic subjects. BSG was chemically characterized, revealing the presence of resistant starch (14.64 g/100 g), arabinoxylans (7.50 g/100 g), β-glucans (1.92 g/100 g) and other soluble fibers (6.43 g/100 g), and bioaccessible ferulic acid (91.3 mg/100 g). For the clinical study, 40 normoglycemic subjects were randomized into two groups, 1 and 2 (n = 20), for a cross-over clinical design and received either BSG extract-based food supplement or placebo. Postprandial blood glucose values were significantly lower than corresponding values in the placebo group after 90 and 120 min, while at the baseline and in the first 60 min, the two glycemic curves overlapped substantially. This improved clinical outcome was corroborated by significant reductions in postprandial insulinemia. None of the subjects reported adverse effects. This study showed that the tested BSG extract-based food supplement improves glucose metabolism and insulinemic response in normoglycemic subjects with at most a mild insulin resistance. MDPI 2022-09-21 /pmc/articles/PMC9572698/ /pubmed/36235569 http://dx.doi.org/10.3390/nu14193916 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ullah, Hammad
Esposito, Cristina
Piccinocchi, Roberto
De Lellis, Lorenza Francesca
Santarcangelo, Cristina
Minno, Alessandro Di
Baldi, Alessandra
Buccato, Daniele Giuseppe
Khan, Ayesha
Piccinocchi, Gaetano
Sacchi, Roberto
Daglia, Maria
Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
title Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
title_full Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
title_fullStr Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
title_full_unstemmed Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
title_short Postprandial Glycemic and Insulinemic Response by a Brewer’s Spent Grain Extract-Based Food Supplement in Subjects with Slightly Impaired Glucose Tolerance: A Monocentric, Randomized, Cross-Over, Double-Blind, Placebo-Controlled Clinical Trial
title_sort postprandial glycemic and insulinemic response by a brewer’s spent grain extract-based food supplement in subjects with slightly impaired glucose tolerance: a monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572698/
https://www.ncbi.nlm.nih.gov/pubmed/36235569
http://dx.doi.org/10.3390/nu14193916
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