An Improved Isotope Labelling Method for Quantifying Deamidated Cobratide Using High-Resolution Quadrupole-Orbitrap Mass Spectrometry

Protein deamidation can severely alter the physicochemical characteristics and biological functions of protein therapeutics. Cobratide is a non-addictive analgesic with wide clinical acceptance. However, the Asn residue at position 48 from the N-terminus of the cobratide amino acid sequence (N48) te...

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Detalles Bibliográficos
Autores principales: Liu, Bo, Huang, Lu, Xu, Rongrong, Fan, Huihong, Wang, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572859/
https://www.ncbi.nlm.nih.gov/pubmed/36234709
http://dx.doi.org/10.3390/molecules27196154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572859/
https://www.ncbi.nlm.nih.gov/pubmed/36234709
http://dx.doi.org/10.3390/molecules27196154

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