Cargando…

An Improved Isotope Labelling Method for Quantifying Deamidated Cobratide Using High-Resolution Quadrupole-Orbitrap Mass Spectrometry

Protein deamidation can severely alter the physicochemical characteristics and biological functions of protein therapeutics. Cobratide is a non-addictive analgesic with wide clinical acceptance. However, the Asn residue at position 48 from the N-terminus of the cobratide amino acid sequence (N48) te...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Bo, Huang, Lu, Xu, Rongrong, Fan, Huihong, Wang, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572859/ https://www.ncbi.nlm.nih.gov/pubmed/36234709 http://dx.doi.org/10.3390/molecules27196154

Ejemplares similares

Characterization and Identification of Prenylated Flavonoids from Artocarpus heterophyllus Lam. Roots by Quadrupole Time-Of-Flight and Linear Trap Quadrupole Orbitrap Mass Spectrometry
por: Ye, Jin-Bao, et al.
Publicado: (2019)

Multi-Mycotoxin Analysis in Durum Wheat Pasta by Liquid Chromatography Coupled to Quadrupole Orbitrap Mass Spectrometry
por: Tolosa, Josefa, et al.
Publicado: (2017)

Analysis of amino acids in human tears by hydrophilic interaction liquid chromatography and quadrupole orbitrap mass spectrometry
por: Du, Chi-Xin, et al.
Publicado: (2019)

Analysis of 27 β-Blockers and Metabolites in Milk Powder by High Performance Liquid Chromatography Coupled to Quadrupole Orbitrap High-Resolution Mass Spectrometry
por: Cheng, Jian-Qiao, et al.
Publicado: (2019)

Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer
por: Michalski, Annette, et al.
Publicado: (2011)

Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Orbitrap High-Resolution Mass Spectrometry for Multi-Residue Analysis of Mycotoxins and Pesticides in Botanical Nutraceuticals
por: Narváez, Alfonso, et al.
Publicado: (2020)

Chemical Constituent Analysis of Ranunculus sceleratus L. Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole-Orbitrap High-Resolution Mass Spectrometry
por: Cao, Shanshan, et al.
Publicado: (2022)

Effect of Thermal Processing on the Metabolic Components of Black Beans on Ultra-High-Performance Liquid Chromatography Coupled with High-Field Quadrupole-Orbitrap High-Resolution Mass Spectrometry
por: Feng, Yuchao, et al.
Publicado: (2022)

Characterization of Fumonisin A-Series by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry
por: Tamura, Masayoshi, et al.
Publicado: (2014)

Determination of Acrylamide in Biscuits by High-Resolution Orbitrap Mass Spectrometry: A Novel Application
por: Fernandes, Cristiana L., et al.
Publicado: (2019)

Multi-Mycotoxin Analysis in Italian Grains Using Ultra-High-Performance Chromatography Coupled to Quadrupole Orbitrap Mass Spectrometry
por: Lima da Silva, Juliane, et al.
Publicado: (2023)

Suspect and non-target screening of chemicals in clothing textiles by reversed-phase liquid chromatography/hybrid quadrupole-Orbitrap mass spectrometry
por: Carlsson, Josefine, et al.
Publicado: (2021)

Validation and Evaluation of High-Resolution Orbitrap Mass Spectrometry on Molecular Characterization of Dissolved Organic Matter
por: Pan, Qiong, et al.
Publicado: (2020)

On the Fine Isotopic Distribution and Limits to Resolution in Mass Spectrometry
por: Dittwald, Piotr, et al.
Publicado: (2015)

Development of a GC/Quadrupole-Orbitrap Mass Spectrometer, Part I: Design and Characterization
por: Peterson, Amelia C., et al.
Publicado: (2014)

High-throughput quantification of carboxymethyl lysine in serum and plasma using high-resolution accurate mass Orbitrap mass spectrometry
por: Rankin, Naomi J, et al.
Publicado: (2019)

Quadrupole storage mass spectrometry
por: March, Raymond E, et al.
Publicado: (1989)

Chemical profiling and quantification of XueBiJing injection, a systematic quality control strategy using UHPLC-Q Exactive hybrid quadrupole-orbitrap high-resolution mass spectrometry
por: Sun, Zhi, et al.
Publicado: (2017)

Pharmacokinetics and Tissue Distribution Study of Pinosylvin in Rats by Ultra-High-Performance Liquid Chromatography Coupled with Linear Trap Quadrupole Orbitrap Mass Spectrometry
por: Fu, Yuhang, et al.
Publicado: (2018)

Rapid Screening of 352 Pesticide Residues in Chrysanthemum Flower by Gas Chromatography Coupled to Quadrupole-Orbitrap Mass Spectrometry with Sin-QuEChERS Nanocolumn Extraction
por: Wang, Yuanyuan, et al.
Publicado: (2022)

Analysis of Isotopic Labeling in Peptide Fragments by Tandem Mass Spectrometry
por: Allen, Doug K., et al.
Publicado: (2014)

Comparison of the Polyphenolic Profile of Medicago sativa L. and Trifolium pratense L. Sprouts in Different Germination Stages Using the UHPLC-Q Exactive Hybrid Quadrupole Orbitrap High-Resolution Mass Spectrometry
por: Chiriac, Elena Roxana, et al.
Publicado: (2020)

Revealing the Toxicity-Enhancing Essence of Glycyrrhiza on Genkwa Flos Based on Ultra-high-performance Liquid Chromatography Coupled With Quadrupole-Orbitrap High-Resolution Mass Spectrometry and Self-Assembled Supramolecular Technology
por: Yang, Yuqin, et al.
Publicado: (2021)

An Entire Process Optimization Strategy for Comprehensive In Vivo Metabolite Profiling of Prucalopride in Rats Based on Ultra-Performance Liquid Chromatography With Q-Exactive Hybrid Quadrupole–Orbitrap High-Resolution Mass Spectrometry
por: Zuo, Lihua, et al.
Publicado: (2021)

Optimization of Ultrafast Proteomics Using an LC-Quadrupole-Orbitrap Mass Spectrometer with Data-Independent Acquisition
por: Ishikawa, Masaki, et al.
Publicado: (2022)

Surfactant Lipidomics of Alveolar Lavage Fluid in Mice Based on Ultra-High-Performance Liquid Chromatography Coupled to Hybrid Quadrupole-Exactive Orbitrap Mass Spectrometry
por: Yang, Rui, et al.
Publicado: (2019)

Target Quantification and Semi-Target Screening of Undesirable Substances in Pear Juices Using Ultra-High-Performance Liquid Chromatography-Quadrupole Orbitrap Mass Spectrometry
por: Narváez, Alfonso, et al.
Publicado: (2020)

Untargeted Ultrahigh-Performance Liquid Chromatography-Hybrid Quadrupole-Orbitrap Mass Spectrometry (UHPLC-HRMS) Metabolomics Reveals Propolis Markers of Greek and Chinese Origin
por: Stavropoulou, Maria-Ioanna, et al.
Publicado: (2021)

Comparative Research of Chemical Profiling in Different Parts of Fissistigma oldhamii by Ultra-High-Performance Liquid Chromatography Coupled with Hybrid Quadrupole-Orbitrap Mass Spectrometry
por: Hu, Haibo, et al.
Publicado: (2021)

Chemical Variations among Shengmaisan-Based TCM Patent Drugs by Ultra-High Performance Liquid Chromatography Coupled with Hybrid Quadrupole Orbitrap Mass Spectrometry
por: Xu, Lulu, et al.
Publicado: (2021)

Quadrupole mass spectrometry and its applications
por: Dawson, Peter H
Publicado: (1995)

Quadrupole mass spectrometry and its applications
por: Dawson, Peter H
Publicado: (1976)

Serum Metabolomics of Tick-Borne Encephalitis Based on Orbitrap-Mass Spectrometry
por: Zhang, Meng, et al.
Publicado: (2021)

Determination of Prenatal Substance Exposure Using Meconium and Orbitrap Mass Spectrometry
por: Hernandez, Atakan, et al.
Publicado: (2022)

The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method
por: Dobrowolska Zakaria, Justyna A., et al.
Publicado: (2022)

Integrated Solid-Phase Extraction, Ultra-High-Performance Liquid Chromatography–Quadrupole-Orbitrap High-Resolution Mass Spectrometry, and Multidimensional Data-Mining Techniques to Unravel the Metabolic Network of Dehydrocostus Lactone in Rats
por: Tian, Yingying, et al.
Publicado: (2022)

Label-free peptide profiling of Orbitrap™ full mass spectra
por: Titulaer, Mark K, et al.
Publicado: (2011)

Detection of Type A Trichothecene Di-Glucosides Produced in Corn by High-Resolution Liquid Chromatography-Orbitrap Mass Spectrometry
por: Nakagawa, Hiroyuki, et al.
Publicado: (2013)

A Simple, Rapid Method for Determination of Melatonin in Plant Tissues by UPLC Coupled with High Resolution Orbitrap Mass Spectrometry
por: Ye, Tiantian, et al.
Publicado: (2017)

Rapid and Accurate Differentiation of Mycobacteroides abscessus Complex Species by Liquid Chromatography-Ultra-High-Resolution Orbitrap™ Mass Spectrometry
por: Bajaj, Amol O., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_65e85ougvnrst8iv0721nei9h5