Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy

Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as w...

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Autores principales: Dajani, Salah, Hill, Virginia B., Kalapurakal, John A., Horbinski, Craig M., Nesbit, Eric G., Sachdev, Sean, Yalamanchili, Amulya, Thomas, Tarita O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572863/
https://www.ncbi.nlm.nih.gov/pubmed/36233828
http://dx.doi.org/10.3390/jcm11195961
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author Dajani, Salah
Hill, Virginia B.
Kalapurakal, John A.
Horbinski, Craig M.
Nesbit, Eric G.
Sachdev, Sean
Yalamanchili, Amulya
Thomas, Tarita O.
author_facet Dajani, Salah
Hill, Virginia B.
Kalapurakal, John A.
Horbinski, Craig M.
Nesbit, Eric G.
Sachdev, Sean
Yalamanchili, Amulya
Thomas, Tarita O.
author_sort Dajani, Salah
collection PubMed
description Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as well as the diagnostic imaging characteristics of this tumor. In addition, factors that affect prognosis such as differentiating progression from treatment effect is discussed. The role of MRI guided radiation therapy and how this technology may provide a mechanism to improve the care of patients with this disease are described.
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spelling pubmed-95728632022-10-17 Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy Dajani, Salah Hill, Virginia B. Kalapurakal, John A. Horbinski, Craig M. Nesbit, Eric G. Sachdev, Sean Yalamanchili, Amulya Thomas, Tarita O. J Clin Med Review Glioblastoma (GBM) continues to be one of the most lethal malignancies and is almost always fatal. In this review article, the role of radiation therapy, systemic therapy, as well as the molecular basis of classifying GBM is described. Technological advances in the treatment of GBM are outlined as well as the diagnostic imaging characteristics of this tumor. In addition, factors that affect prognosis such as differentiating progression from treatment effect is discussed. The role of MRI guided radiation therapy and how this technology may provide a mechanism to improve the care of patients with this disease are described. MDPI 2022-10-10 /pmc/articles/PMC9572863/ /pubmed/36233828 http://dx.doi.org/10.3390/jcm11195961 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dajani, Salah
Hill, Virginia B.
Kalapurakal, John A.
Horbinski, Craig M.
Nesbit, Eric G.
Sachdev, Sean
Yalamanchili, Amulya
Thomas, Tarita O.
Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy
title Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy
title_full Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy
title_fullStr Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy
title_full_unstemmed Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy
title_short Imaging of GBM in the Age of Molecular Markers and MRI Guided Adaptive Radiation Therapy
title_sort imaging of gbm in the age of molecular markers and mri guided adaptive radiation therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572863/
https://www.ncbi.nlm.nih.gov/pubmed/36233828
http://dx.doi.org/10.3390/jcm11195961
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