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Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF(3)CN

We herein describe a general approach to 5-trifluoromethyl 1,2,4-triazoles via the [3 + 2]-cycloaddition of nitrile imines generated in situ from hydrazonyl chloride with CF(3)CN, utilizing 2,2,2-trifluoroacetaldehyde O-(aryl)oxime as the precursor of trifluoroacetonitrile. Various functional groups...

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Detalles Bibliográficos
Autores principales:	Lin, Bo, Zhang, Zipeng, Yao, Yunfei, You, Yi, Weng, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572902/ https://www.ncbi.nlm.nih.gov/pubmed/36235104 http://dx.doi.org/10.3390/molecules27196568

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