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Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura

The aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels of cytokines in female migraine patients. A total of 14 migraineurs with aura, and 12 without aura during their interictal period were compared with 25 controls. Interleukin-8 (IL-8)...

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Autores principales: Plinta, Aelita, Tretjakovs, Peteris, Svirskis, Simons, Logina, Inara, Gersone, Gita, Jurka, Antra, Mikelsone, Indra, Blumfelds, Leons, Mackevics, Vitolds, Bahs, Guntis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572946/
https://www.ncbi.nlm.nih.gov/pubmed/36233564
http://dx.doi.org/10.3390/jcm11195696
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author Plinta, Aelita
Tretjakovs, Peteris
Svirskis, Simons
Logina, Inara
Gersone, Gita
Jurka, Antra
Mikelsone, Indra
Blumfelds, Leons
Mackevics, Vitolds
Bahs, Guntis
author_facet Plinta, Aelita
Tretjakovs, Peteris
Svirskis, Simons
Logina, Inara
Gersone, Gita
Jurka, Antra
Mikelsone, Indra
Blumfelds, Leons
Mackevics, Vitolds
Bahs, Guntis
author_sort Plinta, Aelita
collection PubMed
description The aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels of cytokines in female migraine patients. A total of 14 migraineurs with aura, and 12 without aura during their interictal period were compared with 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor alpha (TGF-α), and plasminogen activator inhibitor-1 (PAI-1) were measured. Migraineurs have elevated levels of IL-8, but decreased serum levels of PAI-1 and sICAM-1 during the interictal period, regardless of aura. BMI correlates with BP, and also with IFN-γ and MMP-9 only in patients with aura. There are three correlations in migraine patients with aura that are absent in patients without aura: between IL-8 and PAI-1; MMP-9 and IL-8; and IL-8 and sICAM-1. Migraineurs without aura, on the other hand, have correlations that patients with aura do not have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between TGF-α and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well as between sVCAM-1 and MCP-1). PAI-1, TGF, and MMP-9 could be used as biomarkers to distinguish migraineurs from healthy individuals.
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spelling pubmed-95729462022-10-17 Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura Plinta, Aelita Tretjakovs, Peteris Svirskis, Simons Logina, Inara Gersone, Gita Jurka, Antra Mikelsone, Indra Blumfelds, Leons Mackevics, Vitolds Bahs, Guntis J Clin Med Article The aim of the study was to clarify correlations between body mass index (BMI), blood pressure (BP), and serum levels of cytokines in female migraine patients. A total of 14 migraineurs with aura, and 12 without aura during their interictal period were compared with 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor alpha (TGF-α), and plasminogen activator inhibitor-1 (PAI-1) were measured. Migraineurs have elevated levels of IL-8, but decreased serum levels of PAI-1 and sICAM-1 during the interictal period, regardless of aura. BMI correlates with BP, and also with IFN-γ and MMP-9 only in patients with aura. There are three correlations in migraine patients with aura that are absent in patients without aura: between IL-8 and PAI-1; MMP-9 and IL-8; and IL-8 and sICAM-1. Migraineurs without aura, on the other hand, have correlations that patients with aura do not have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between TGF-α and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well as between sVCAM-1 and MCP-1). PAI-1, TGF, and MMP-9 could be used as biomarkers to distinguish migraineurs from healthy individuals. MDPI 2022-09-26 /pmc/articles/PMC9572946/ /pubmed/36233564 http://dx.doi.org/10.3390/jcm11195696 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Plinta, Aelita
Tretjakovs, Peteris
Svirskis, Simons
Logina, Inara
Gersone, Gita
Jurka, Antra
Mikelsone, Indra
Blumfelds, Leons
Mackevics, Vitolds
Bahs, Guntis
Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura
title Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura
title_full Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura
title_fullStr Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura
title_full_unstemmed Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura
title_short Association of Body Mass Index, Blood Pressure, and Interictal Serum Levels of Cytokines in Migraine with and without Aura
title_sort association of body mass index, blood pressure, and interictal serum levels of cytokines in migraine with and without aura
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572946/
https://www.ncbi.nlm.nih.gov/pubmed/36233564
http://dx.doi.org/10.3390/jcm11195696
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