Cargando…

Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects

Cardiac and hepatotoxicities are major concerns in the development of new drugs. Better alternatives to other treatments are being sought to protect these vital organs from the toxicities of these pharmaceuticals. In this regard, a preclinical study is designed to investigate the histopathological e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qayyum, Muhammad Imran, Ullah, Sami, Rashid, Umer, Sadiq, Abdul, Obaidullah, Mahnashi, Mater H., Alshehri, Osama M., Jalal, Mohammed M., Alzahrani, Khalid J., Halawani, Ibrahim F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573045/ https://www.ncbi.nlm.nih.gov/pubmed/36234730 http://dx.doi.org/10.3390/molecules27196199

Ejemplares similares

Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-α-Amylase, and Anti-α-Glucosidase: In Vitro and In Silico Approaches
por: Alshehri, Osama M., et al.
Publicado: (2022)

New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies
por: Huneif, Mohammed A., et al.
Publicado: (2023)

Exploration of Succinimide Derivative as a Multi-Target, Anti-Diabetic Agent: In Vitro and In Vivo Approaches
por: Mahnashi, Mater H., et al.
Publicado: (2023)

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives
por: Ahmad, Ashfaq, et al.
Publicado: (2020)

In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer’s Disease
por: Mahnashi, Mater H., et al.
Publicado: (2022)

Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches
por: Mahnashi, Mater H., et al.
Publicado: (2021)

Isolation, In Vitro and In Silico Anti-Alzheimer and Anti-Inflammatory Studies on Phytosteroids from Aerial Parts of Fragaria × ananassa Duch
por: Mahnashi, Mater H., et al.
Publicado: (2022)

Succinimid of Mercury
por: Wright, B. L.
Publicado: (1916)

Vasorelaxant and Antihypertensive Effects of Bergenin on Isolated Rat Aorta and High Salt-Induced Hypertensive Rats
por: Ahmad, Taseer, et al.
Publicado: (2022)

Molecular Docking and Preclinical Study of Five-Membered S,S-Palladaheterocycle as Hepatoprotective Agent
por: Akhmadiev, Nail Salavatovich, et al.
Publicado: (2019)

Synthesis of Michael Adducts as Key Building Blocks for Potential Analgesic Drugs: In vitro, in vivo and in silico Explorations
por: Ahmad, Sajjad, et al.
Publicado: (2021)

3-(((1S,3S)-3-((R)-Hydroxy(4-(trifluoromethyl)phenyl)methyl)-4-oxocyclohexyl)methyl)pentane-2,4-dione: Design and Synthesis of New Stereopure Multi-Target Antidiabetic Agent
por: Sadiq, Abdul, et al.
Publicado: (2022)

Cytotoxicity, anti-angiogenic, anti-tumor and molecular docking studies on phytochemicals isolated from Polygonum hydropiper L.
por: Mahnashi, Mater H., et al.
Publicado: (2021)

Synthesis, anticholinesterase and antioxidant potentials of ketoesters derivatives of succinimides: a possible role in the management of Alzheimer’s
por: Sadiq, Abdul, et al.
Publicado: (2015)

Facts Regarding Succinimide of Mercury
por: Reed, Geo. H.
Publicado: (1916)

Neuroprotective potentials of selected natural edible oils using enzyme inhibitory, kinetic and simulation approaches
por: Mahnashi, Mater H., et al.
Publicado: (2021)

Phytochemical Analysis, α-Glucosidase and Amylase Inhibitory, and Molecular Docking Studies on Persicaria hydropiper L. Leaves Essential Oils
por: Mahnashi, Mater H., et al.
Publicado: (2022)

N-(3-Chlorophenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2011)

N-(3-Methylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(4-Methylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(2-Chlorophenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

HPLC-DAD phenolics analysis, α-glucosidase, α-amylase inhibitory, molecular docking and nutritional profiles of Persicaria hydropiper L.
por: Mahnashi, Mater H., et al.
Publicado: (2022)

A Reliable Auto-Robust Analysis of Blood Smear Images for Classification of Microcytic Hypochromic Anemia Using Gray Level Matrices and Gabor Feature Bank
por: Azam, Bakht, et al.
Publicado: (2020)

N-(2,4-Dimethylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(2,3-Dimethylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(2,6-Dimethylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide
por: Waheed, Bushra, et al.
Publicado: (2022)

Anti-Inflammatory, Analgesic and Antioxidant Potential of New (2S,3S)-2-(4-isopropylbenzyl)-2-methyl-4-nitro-3-phenylbutanals and Their Corresponding Carboxylic Acids through In Vitro, In Silico and In Vivo Studies
por: Mahmood, Fawad, et al.
Publicado: (2022)

Phytochemistry, anti-diabetic and antioxidant potentials of Allium consanguineum Kunth
por: Mahnashi, Mater H., et al.
Publicado: (2022)

Cardioprotective Potential of Aqueous Extract of Fumaria indica on Isoproterenol-Induced Myocardial Infarction in SD Rats
por: Sajid, Aimen, et al.
Publicado: (2022)

An Electrochemical DNA Microbiosensor Based on Succinimide-Modified Acrylic Microspheres
por: Ulianas, Alizar, et al.
Publicado: (2012)

Crystal structure of N-(3-hydroxyphenyl)succinimide
por: Suchetan, P. A., et al.
Publicado: (2014)

Juglone from Walnut Produces Cardioprotective Effects against Isoproterenol-Induced Myocardial Injury in SD Rats
por: Ahmad, Taseer, et al.
Publicado: (2022)

Antioxidant Molecules Isolated from Edible Prostrate Knotweed: Rational Derivatization to Produce More Potent Molecules
por: Mahnashi, Mater H., et al.
Publicado: (2022)

Synthesis, Molecular Docking Study, and Biological Evaluation of New 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N’-(2-(substituted)acetyl)benzohydrazides as Dual Enoyl ACP Reductase and DHFR Enzyme Inhibitors
por: Mahnashi, Mater H., et al.
Publicado: (2023)

Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies
por: Jabeen, Muafia, et al.
Publicado: (2018)

Phytochemical Analysis, Total Phenolic, Flavonoid Contents, and Anticancer Evaluations of Solvent Extracts and Saponins of H. digitata
por: Alshehri, Osama M., et al.
Publicado: (2022)

On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins
por: Vamisetti, Ganga B., et al.
Publicado: (2020)

Corrigendum: Ursolic Acid Hydrazide Based Organometallic Complexes: Synthesis, Characterization, Antibacterial, Antioxidant, and Docking Studies
por: Jabeen, Muafia, et al.
Publicado: (2018)

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action
por: Lecour, Sandrine, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_85fo4hhb8f9kfrine688cut49c