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Hypericum Genus as a Natural Source for Biologically Active Compounds

Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondar...

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Autores principales: Caldeira, Gonçalo Infante, Gouveia, Luís Pleno, Serrano, Rita, Silva, Olga Duarte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573133/
https://www.ncbi.nlm.nih.gov/pubmed/36235373
http://dx.doi.org/10.3390/plants11192509
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author Caldeira, Gonçalo Infante
Gouveia, Luís Pleno
Serrano, Rita
Silva, Olga Duarte
author_facet Caldeira, Gonçalo Infante
Gouveia, Luís Pleno
Serrano, Rita
Silva, Olga Duarte
author_sort Caldeira, Gonçalo Infante
collection PubMed
description Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondary metabolites previously shown, and the in vitro and/or in vivo cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, and hepatoprotective activities, as well as the acetylcholinesterase and monoamine oxidase inhibitory activities. We conducted a systematic bibliographic search according to the Cochrane Collaboration guidelines to answer the question: “What is known about plants of Hypericum genus as a source of natural products with potential clinical biological activity?” We documented 414 different natural products with confirmed in vitro/in vivo biological activities, and 58 different Hypericum plant species as sources for these natural products. Phloroglucinols, acylphloroglucinols, xanthones, and benzophenones were the main chemical classes identified. The selective cytotoxicity against tumor cells, cell protection, anti-inflammatory, antimicrobial, antidepressant, anti-Alzheimer’s, and adipogenesis-inhibition biological activities are described. Acylphloroglucinols were the most frequent compounds with anticancer and cell-protection mechanisms. To date, no work has been published with a full descriptive list directly relating secondary metabolites to their species of origin, plant parts used, extraction methodologies, mechanisms of action, and biological activities.
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spelling pubmed-95731332022-10-17 Hypericum Genus as a Natural Source for Biologically Active Compounds Caldeira, Gonçalo Infante Gouveia, Luís Pleno Serrano, Rita Silva, Olga Duarte Plants (Basel) Systematic Review Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondary metabolites previously shown, and the in vitro and/or in vivo cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, and hepatoprotective activities, as well as the acetylcholinesterase and monoamine oxidase inhibitory activities. We conducted a systematic bibliographic search according to the Cochrane Collaboration guidelines to answer the question: “What is known about plants of Hypericum genus as a source of natural products with potential clinical biological activity?” We documented 414 different natural products with confirmed in vitro/in vivo biological activities, and 58 different Hypericum plant species as sources for these natural products. Phloroglucinols, acylphloroglucinols, xanthones, and benzophenones were the main chemical classes identified. The selective cytotoxicity against tumor cells, cell protection, anti-inflammatory, antimicrobial, antidepressant, anti-Alzheimer’s, and adipogenesis-inhibition biological activities are described. Acylphloroglucinols were the most frequent compounds with anticancer and cell-protection mechanisms. To date, no work has been published with a full descriptive list directly relating secondary metabolites to their species of origin, plant parts used, extraction methodologies, mechanisms of action, and biological activities. MDPI 2022-09-26 /pmc/articles/PMC9573133/ /pubmed/36235373 http://dx.doi.org/10.3390/plants11192509 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Caldeira, Gonçalo Infante
Gouveia, Luís Pleno
Serrano, Rita
Silva, Olga Duarte
Hypericum Genus as a Natural Source for Biologically Active Compounds
title Hypericum Genus as a Natural Source for Biologically Active Compounds
title_full Hypericum Genus as a Natural Source for Biologically Active Compounds
title_fullStr Hypericum Genus as a Natural Source for Biologically Active Compounds
title_full_unstemmed Hypericum Genus as a Natural Source for Biologically Active Compounds
title_short Hypericum Genus as a Natural Source for Biologically Active Compounds
title_sort hypericum genus as a natural source for biologically active compounds
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573133/
https://www.ncbi.nlm.nih.gov/pubmed/36235373
http://dx.doi.org/10.3390/plants11192509
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