AVA-NP-695 Selectively Inhibits ENPP1 to Activate STING Pathway and Abrogate Tumor Metastasis in 4T1 Breast Cancer Syngeneic Mouse Model

Cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor that synthesizes cyclic guanosine monophosphate–adenosine monophosphate (2′3′-cGAMP) from ATP and GTP. 2′3′-cGAMP activates the stimulator of interferon genes (STING) pathway, resulting in the production of interferons and pro-inflammatory c...

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Detalles Bibliográficos
Autores principales: Goswami, Avijit, Deb, Barnali, Goyal, Sandeep, Gosavi, Abhishek, Mali, Mukund, Martis, Ashwita M., Khurana, Princy, Gangar, Mukesh, Raykar, Digambar, Mohanty, Ankita, Kulkarni, Aditya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573294/
https://www.ncbi.nlm.nih.gov/pubmed/36235254
http://dx.doi.org/10.3390/molecules27196721

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