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Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey

Background: The effects of the fat-to-muscle ratio (FMR) on hyperuricemia and a reduction in the estimated glomerular filtration rate (eGFR) are still unclear. Methods: Data from the China National Health Survey were used to explore the associations of the FMR with hyperuricemia and reduced eGFR. Th...

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Autores principales: He, Huijing, Pan, Li, Wang, Dingming, Liu, Feng, Du, Jianwei, Pa, Lize, Wang, Xianghua, Cui, Ze, Ren, Xiaolan, Wang, Hailing, Peng, Xia, Zhao, Jingbo, Shan, Guangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573307/
https://www.ncbi.nlm.nih.gov/pubmed/36235845
http://dx.doi.org/10.3390/nu14194193
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author He, Huijing
Pan, Li
Wang, Dingming
Liu, Feng
Du, Jianwei
Pa, Lize
Wang, Xianghua
Cui, Ze
Ren, Xiaolan
Wang, Hailing
Peng, Xia
Zhao, Jingbo
Shan, Guangliang
author_facet He, Huijing
Pan, Li
Wang, Dingming
Liu, Feng
Du, Jianwei
Pa, Lize
Wang, Xianghua
Cui, Ze
Ren, Xiaolan
Wang, Hailing
Peng, Xia
Zhao, Jingbo
Shan, Guangliang
author_sort He, Huijing
collection PubMed
description Background: The effects of the fat-to-muscle ratio (FMR) on hyperuricemia and a reduction in the estimated glomerular filtration rate (eGFR) are still unclear. Methods: Data from the China National Health Survey were used to explore the associations of the FMR with hyperuricemia and reduced eGFR. The fat mass and muscle mass were measured through bioelectrical impedance analysis. Mediation analysis was used to estimate the mediated effect of hyperuricemia on the association between the FMR and reduced eGFR. Results: A total of 31171 participants were included. For hyperuricemia, compared with the Q1 of the FMR, the ORs (95% CI) of Q2, Q3 and Q4 were 1.60 (1.32–1.95), 2.31 (1.91–2.80) and 2.71 (2.15–3.43) in men and 1.91 (1.56–2.34), 2.67 (2.12–3.36) and 4.47 (3.40–5.89) in women. For the reduced eGFR, the ORs (95% CI) of Q2, Q3 and Q4 of the FMR were 1.48 (1.18–1.87), 1.38 (1.05–1.82) and 1.45 (1.04–2.04) in men aged 40–59, but no positive association was found in younger men or in women. Hyperuricemia mediated the association between the FMR and reduced eGFR in men. The OR (95% CI) of the indirect effect was 1.08 (1.05–1.10), accounting for 35.11% of the total effect. Conclusions: The FMR was associated with hyperuricemia and reduced eGFR, and the associations varied based on sex and age. The effect of the FMR on the reduced eGFR was significantly mediated by hyperuricemia in men.
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spelling pubmed-95733072022-10-17 Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey He, Huijing Pan, Li Wang, Dingming Liu, Feng Du, Jianwei Pa, Lize Wang, Xianghua Cui, Ze Ren, Xiaolan Wang, Hailing Peng, Xia Zhao, Jingbo Shan, Guangliang Nutrients Article Background: The effects of the fat-to-muscle ratio (FMR) on hyperuricemia and a reduction in the estimated glomerular filtration rate (eGFR) are still unclear. Methods: Data from the China National Health Survey were used to explore the associations of the FMR with hyperuricemia and reduced eGFR. The fat mass and muscle mass were measured through bioelectrical impedance analysis. Mediation analysis was used to estimate the mediated effect of hyperuricemia on the association between the FMR and reduced eGFR. Results: A total of 31171 participants were included. For hyperuricemia, compared with the Q1 of the FMR, the ORs (95% CI) of Q2, Q3 and Q4 were 1.60 (1.32–1.95), 2.31 (1.91–2.80) and 2.71 (2.15–3.43) in men and 1.91 (1.56–2.34), 2.67 (2.12–3.36) and 4.47 (3.40–5.89) in women. For the reduced eGFR, the ORs (95% CI) of Q2, Q3 and Q4 of the FMR were 1.48 (1.18–1.87), 1.38 (1.05–1.82) and 1.45 (1.04–2.04) in men aged 40–59, but no positive association was found in younger men or in women. Hyperuricemia mediated the association between the FMR and reduced eGFR in men. The OR (95% CI) of the indirect effect was 1.08 (1.05–1.10), accounting for 35.11% of the total effect. Conclusions: The FMR was associated with hyperuricemia and reduced eGFR, and the associations varied based on sex and age. The effect of the FMR on the reduced eGFR was significantly mediated by hyperuricemia in men. MDPI 2022-10-08 /pmc/articles/PMC9573307/ /pubmed/36235845 http://dx.doi.org/10.3390/nu14194193 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
He, Huijing
Pan, Li
Wang, Dingming
Liu, Feng
Du, Jianwei
Pa, Lize
Wang, Xianghua
Cui, Ze
Ren, Xiaolan
Wang, Hailing
Peng, Xia
Zhao, Jingbo
Shan, Guangliang
Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey
title Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey
title_full Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey
title_fullStr Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey
title_full_unstemmed Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey
title_short Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey
title_sort fat-to-muscle ratio is independently associated with hyperuricemia and a reduced estimated glomerular filtration rate in chinese adults: the china national health survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573307/
https://www.ncbi.nlm.nih.gov/pubmed/36235845
http://dx.doi.org/10.3390/nu14194193
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