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Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies

Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe...

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Autores principales: Jaskiewicz, Lukasz, Hejne, Karolina, Szostak, Blazej, Osowiecka, Karolina, Skowronski, Mariusz T., Lepiarczyk, Ewa, Doboszynska, Anna, Majewska, Marta, Kordowitzki, Pawel, Skowronska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573329/
https://www.ncbi.nlm.nih.gov/pubmed/36233821
http://dx.doi.org/10.3390/jcm11195954
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author Jaskiewicz, Lukasz
Hejne, Karolina
Szostak, Blazej
Osowiecka, Karolina
Skowronski, Mariusz T.
Lepiarczyk, Ewa
Doboszynska, Anna
Majewska, Marta
Kordowitzki, Pawel
Skowronska, Agnieszka
author_facet Jaskiewicz, Lukasz
Hejne, Karolina
Szostak, Blazej
Osowiecka, Karolina
Skowronski, Mariusz T.
Lepiarczyk, Ewa
Doboszynska, Anna
Majewska, Marta
Kordowitzki, Pawel
Skowronska, Agnieszka
author_sort Jaskiewicz, Lukasz
collection PubMed
description Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (p = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (p < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (p < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (p = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients.
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spelling pubmed-95733292022-10-17 Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies Jaskiewicz, Lukasz Hejne, Karolina Szostak, Blazej Osowiecka, Karolina Skowronski, Mariusz T. Lepiarczyk, Ewa Doboszynska, Anna Majewska, Marta Kordowitzki, Pawel Skowronska, Agnieszka J Clin Med Article Aquaporins (AQPs) are highly conserved channel proteins which are mainly responsible for the exchange of water and small molecules and have shown to play a pivotal role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer seen in patients in Europe and the United States. However, in patients it is often not diagnosed until the advanced tumor stage is present. Previous studies provided strong evidence that some members of the AQP family could serve as clinical biomarkers for different diseases. Therefore, we aimed to investigate how AQP3 and AQP4 protein expression in lung adenocarcinoma (ADC) biopsy samples correlate with clinical and pathological parameters. The protein expression of AQP3 and AQP4 was analyzed based on immunohistochemical staining. AQP3 protein was observed in the cytoplasmic membrane of cancer tissue in 82% of lung samples. Significant differences in relative protein expression of AQP3 were noted between advanced age patients compared to younger counterparts (p = 0.017). A high expression of AQP3 was significant in cancer tissue when compared to the control group (p < 0.001), whereas a low AQP4 membrane expression was noted as significantly common in cancer tissue compared to non-neoplastic lung tissue (p < 0.001). Moreover, a low AQP4 membrane expression was positively correlated with a more advanced disease status, e.g., lymph node metastases (p = 0.046). Based on our findings, AQP3 and AQP4 could be used as biomarkers in ADC patients. MDPI 2022-10-09 /pmc/articles/PMC9573329/ /pubmed/36233821 http://dx.doi.org/10.3390/jcm11195954 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jaskiewicz, Lukasz
Hejne, Karolina
Szostak, Blazej
Osowiecka, Karolina
Skowronski, Mariusz T.
Lepiarczyk, Ewa
Doboszynska, Anna
Majewska, Marta
Kordowitzki, Pawel
Skowronska, Agnieszka
Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
title Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
title_full Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
title_fullStr Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
title_full_unstemmed Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
title_short Expression Profiles of AQP3 and AQP4 in Lung Adenocarcinoma Samples Generated via Bronchoscopic Biopsies
title_sort expression profiles of aqp3 and aqp4 in lung adenocarcinoma samples generated via bronchoscopic biopsies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573329/
https://www.ncbi.nlm.nih.gov/pubmed/36233821
http://dx.doi.org/10.3390/jcm11195954
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