Cargando…
Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation
This study focused on the preventive effects of the extracts of Rhus chinensis Mill. (RCM) fruits on cholestasis induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in mice. The results showed that RCM extracts could significantly ameliorate DDC-induced cholestasis via multiple mechanisms, in...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573408/ https://www.ncbi.nlm.nih.gov/pubmed/36235742 http://dx.doi.org/10.3390/nu14194090 |
_version_ | 1784810862348861440 |
---|---|
author | Sun, Yilin Cai, Shengbao Zhang, Yuanyue Ma, Nan Yi, Junjie Hu, Xiaosong Wang, Tao |
author_facet | Sun, Yilin Cai, Shengbao Zhang, Yuanyue Ma, Nan Yi, Junjie Hu, Xiaosong Wang, Tao |
author_sort | Sun, Yilin |
collection | PubMed |
description | This study focused on the preventive effects of the extracts of Rhus chinensis Mill. (RCM) fruits on cholestasis induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in mice. The results showed that RCM extracts could significantly ameliorate DDC-induced cholestasis via multiple mechanisms, including (1) alleviating liver damage via enhancing antioxidant capacity, such as increasing the contents of glutathione, superoxide dismutase, and catalase and inhibiting the levels of malondialdehyde; (2) preventing liver inflammation by suppressing NF-κB pathway and reducing proinflammatory cytokines secretion (e.g., tumor necrosis factor-α, interleukin-1β, and interleukin-6); (3) inhibiting liver fibrosis and collagen deposition by regulating the expression of transforming growth factor-β and α-smooth muscle actin; (4) modulating abnormal bile acid metabolism through increasing the expression of bile salt export pump and multidrug resistance-associated protein 2. This study was the first to elucidate the potential preventive effect of RCM extracts on DDC-induced cholestasis in mice from multiple pathways, which suggested that RCM fruits could be considered as a potential dietary supplement to prevent cholestasis. |
format | Online Article Text |
id | pubmed-9573408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95734082022-10-17 Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation Sun, Yilin Cai, Shengbao Zhang, Yuanyue Ma, Nan Yi, Junjie Hu, Xiaosong Wang, Tao Nutrients Article This study focused on the preventive effects of the extracts of Rhus chinensis Mill. (RCM) fruits on cholestasis induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in mice. The results showed that RCM extracts could significantly ameliorate DDC-induced cholestasis via multiple mechanisms, including (1) alleviating liver damage via enhancing antioxidant capacity, such as increasing the contents of glutathione, superoxide dismutase, and catalase and inhibiting the levels of malondialdehyde; (2) preventing liver inflammation by suppressing NF-κB pathway and reducing proinflammatory cytokines secretion (e.g., tumor necrosis factor-α, interleukin-1β, and interleukin-6); (3) inhibiting liver fibrosis and collagen deposition by regulating the expression of transforming growth factor-β and α-smooth muscle actin; (4) modulating abnormal bile acid metabolism through increasing the expression of bile salt export pump and multidrug resistance-associated protein 2. This study was the first to elucidate the potential preventive effect of RCM extracts on DDC-induced cholestasis in mice from multiple pathways, which suggested that RCM fruits could be considered as a potential dietary supplement to prevent cholestasis. MDPI 2022-10-01 /pmc/articles/PMC9573408/ /pubmed/36235742 http://dx.doi.org/10.3390/nu14194090 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sun, Yilin Cai, Shengbao Zhang, Yuanyue Ma, Nan Yi, Junjie Hu, Xiaosong Wang, Tao Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation |
title | Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation |
title_full | Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation |
title_fullStr | Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation |
title_full_unstemmed | Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation |
title_short | Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation |
title_sort | protective effect of rhus chinensis mill. fruits on 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis in mice via ameliorating oxidative stress and inflammation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573408/ https://www.ncbi.nlm.nih.gov/pubmed/36235742 http://dx.doi.org/10.3390/nu14194090 |
work_keys_str_mv | AT sunyilin protectiveeffectofrhuschinensismillfruitson35diethoxycarbonyl14dihydrocollidineinducedcholestasisinmiceviaamelioratingoxidativestressandinflammation AT caishengbao protectiveeffectofrhuschinensismillfruitson35diethoxycarbonyl14dihydrocollidineinducedcholestasisinmiceviaamelioratingoxidativestressandinflammation AT zhangyuanyue protectiveeffectofrhuschinensismillfruitson35diethoxycarbonyl14dihydrocollidineinducedcholestasisinmiceviaamelioratingoxidativestressandinflammation AT manan protectiveeffectofrhuschinensismillfruitson35diethoxycarbonyl14dihydrocollidineinducedcholestasisinmiceviaamelioratingoxidativestressandinflammation AT yijunjie protectiveeffectofrhuschinensismillfruitson35diethoxycarbonyl14dihydrocollidineinducedcholestasisinmiceviaamelioratingoxidativestressandinflammation AT huxiaosong protectiveeffectofrhuschinensismillfruitson35diethoxycarbonyl14dihydrocollidineinducedcholestasisinmiceviaamelioratingoxidativestressandinflammation AT wangtao protectiveeffectofrhuschinensismillfruitson35diethoxycarbonyl14dihydrocollidineinducedcholestasisinmiceviaamelioratingoxidativestressandinflammation |