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Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software
Background: To explore the agreement between clinical judgment and Guided Progression Analysis II (GPAII) in the evaluation of visual fields (VF) progression in patients with glaucoma. Methods: Three glaucoma experts and three general ophthalmologists were asked to rate the VF series by classifying...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573472/ https://www.ncbi.nlm.nih.gov/pubmed/36233376 http://dx.doi.org/10.3390/jcm11195508 |
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author | Roberti, Gloria Michelessi, Manuele Tanga, Lucia Belfonte, Luca Del Grande, Laura Maria Bruno, Marisa Oddone, Francesco |
author_facet | Roberti, Gloria Michelessi, Manuele Tanga, Lucia Belfonte, Luca Del Grande, Laura Maria Bruno, Marisa Oddone, Francesco |
author_sort | Roberti, Gloria |
collection | PubMed |
description | Background: To explore the agreement between clinical judgment and Guided Progression Analysis II (GPAII) in the evaluation of visual fields (VF) progression in patients with glaucoma. Methods: Three glaucoma experts and three general ophthalmologists were asked to rate the VF series by classifying them as progressive through the observation of the overview report. The agreement between clinical judgment and GPAII event analysis (EA) and trend analysis (TA) was assessed by Cohen statistic. The sensitivity and specificity of clinical judgment in detecting the presence of progression was evaluated considering the results of GPAII as the reference standard. Results: 66 VF series were included in the study. Glaucoma experts, general ophthalmologists, GPAII EA, and GPAII TA found progression in 39%, 38%, 15%, and 21% of the VF series (p < 0.05). The clinical judgment of glaucoma experts and general ophthalmologists was discordant with GPAII EA in 27.2% and 28.7% (k = 0.35, 95% CI 0.15–0.56 and k = 0.30, 95% CI 0.09–0.52) and with GPAII TA in 21.2% and 25.7% of the VF series examined (k = 0.51, 95% CI 0.31–0.72 and k = 0.41, 95% CI 0.18–0.62). Considering the GPAII EA and TA as reference standard, glaucoma experts showed a sensitivity of 90% and 92.8% and a specificity of 69.6% and 75%, while general ophthalmologists showed a sensitivity of 80% and 78.5% and a specificity of 69.6% and 73%. Conclusions: The agreement between clinical judgment and GPAII ranges from fair to moderate. Glaucoma experts showed better ability than general ophthalmologists in detecting VF progression. |
format | Online Article Text |
id | pubmed-9573472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95734722022-10-17 Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software Roberti, Gloria Michelessi, Manuele Tanga, Lucia Belfonte, Luca Del Grande, Laura Maria Bruno, Marisa Oddone, Francesco J Clin Med Article Background: To explore the agreement between clinical judgment and Guided Progression Analysis II (GPAII) in the evaluation of visual fields (VF) progression in patients with glaucoma. Methods: Three glaucoma experts and three general ophthalmologists were asked to rate the VF series by classifying them as progressive through the observation of the overview report. The agreement between clinical judgment and GPAII event analysis (EA) and trend analysis (TA) was assessed by Cohen statistic. The sensitivity and specificity of clinical judgment in detecting the presence of progression was evaluated considering the results of GPAII as the reference standard. Results: 66 VF series were included in the study. Glaucoma experts, general ophthalmologists, GPAII EA, and GPAII TA found progression in 39%, 38%, 15%, and 21% of the VF series (p < 0.05). The clinical judgment of glaucoma experts and general ophthalmologists was discordant with GPAII EA in 27.2% and 28.7% (k = 0.35, 95% CI 0.15–0.56 and k = 0.30, 95% CI 0.09–0.52) and with GPAII TA in 21.2% and 25.7% of the VF series examined (k = 0.51, 95% CI 0.31–0.72 and k = 0.41, 95% CI 0.18–0.62). Considering the GPAII EA and TA as reference standard, glaucoma experts showed a sensitivity of 90% and 92.8% and a specificity of 69.6% and 75%, while general ophthalmologists showed a sensitivity of 80% and 78.5% and a specificity of 69.6% and 73%. Conclusions: The agreement between clinical judgment and GPAII ranges from fair to moderate. Glaucoma experts showed better ability than general ophthalmologists in detecting VF progression. MDPI 2022-09-20 /pmc/articles/PMC9573472/ /pubmed/36233376 http://dx.doi.org/10.3390/jcm11195508 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Roberti, Gloria Michelessi, Manuele Tanga, Lucia Belfonte, Luca Del Grande, Laura Maria Bruno, Marisa Oddone, Francesco Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software |
title | Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software |
title_full | Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software |
title_fullStr | Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software |
title_full_unstemmed | Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software |
title_short | Glaucoma Progression Diagnosis: The Agreement between Clinical Judgment and Statistical Software |
title_sort | glaucoma progression diagnosis: the agreement between clinical judgment and statistical software |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573472/ https://www.ncbi.nlm.nih.gov/pubmed/36233376 http://dx.doi.org/10.3390/jcm11195508 |
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