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Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients
Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF and P-pg serum levels in SR in SLE. Methods: C...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573564/ https://www.ncbi.nlm.nih.gov/pubmed/36235275 http://dx.doi.org/10.3390/molecules27196741 |
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author | Beltrán-Ramírez, Alberto Muñoz-Valle, José Francisco Gamez-Nava, Jorge I. Saldaña-Cruz, Ana Miriam Gonzalez-Lopez, Laura Padilla-Ortega, Alejandro Arias-García, Francisco I. Sánchez-Zuno, Gabriela Athziri Nava-Valdivia, Cesar Arturo Ponce-Guarneros, Juan Manuel García-Galindo, Jesús Jonathan Perez-Guerrero, Edsaúl Emilio |
author_facet | Beltrán-Ramírez, Alberto Muñoz-Valle, José Francisco Gamez-Nava, Jorge I. Saldaña-Cruz, Ana Miriam Gonzalez-Lopez, Laura Padilla-Ortega, Alejandro Arias-García, Francisco I. Sánchez-Zuno, Gabriela Athziri Nava-Valdivia, Cesar Arturo Ponce-Guarneros, Juan Manuel García-Galindo, Jesús Jonathan Perez-Guerrero, Edsaúl Emilio |
author_sort | Beltrán-Ramírez, Alberto |
collection | PubMed |
description | Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF and P-pg serum levels in SR in SLE. Methods: Case–control study including 188 SLE patients who were divided into two groups (90 in the steroid-resistant group and 98 in the steroid-sensitive (SS) group) and 35 healthy controls. MIF and P-gp serum levels were determined by ELISA. Multivariable logistic regression and chi-squared automatic interaction detection (CHAID) were used to explore risk factors for SR. Results: The steroid-resistant group presented higher MIF and P-gp serum levels in comparison with the SS (p < 0.001) and reference (p < 0.001) groups. MIF correlated positively with P-gp (rho = 0.41, p < 0.001). MIF (≥15.75 ng/mL) and P-gp (≥15.22 ng/mL) were a risk factor for SR (OR = 2.29, OR = 5.27). CHAID identified high P-gp as the main risk factor for SR and high MIF as the second risk factor in those patients with low P-gp. Conclusions: An association between MIF and P-gp serum levels was observed in SR. CHAID identified P-gp ≥ 15.22 ng/mL as the main risk factor for SR. More studies are needed to validate these results. |
format | Online Article Text |
id | pubmed-9573564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95735642022-10-17 Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients Beltrán-Ramírez, Alberto Muñoz-Valle, José Francisco Gamez-Nava, Jorge I. Saldaña-Cruz, Ana Miriam Gonzalez-Lopez, Laura Padilla-Ortega, Alejandro Arias-García, Francisco I. Sánchez-Zuno, Gabriela Athziri Nava-Valdivia, Cesar Arturo Ponce-Guarneros, Juan Manuel García-Galindo, Jesús Jonathan Perez-Guerrero, Edsaúl Emilio Molecules Article Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF and P-pg serum levels in SR in SLE. Methods: Case–control study including 188 SLE patients who were divided into two groups (90 in the steroid-resistant group and 98 in the steroid-sensitive (SS) group) and 35 healthy controls. MIF and P-gp serum levels were determined by ELISA. Multivariable logistic regression and chi-squared automatic interaction detection (CHAID) were used to explore risk factors for SR. Results: The steroid-resistant group presented higher MIF and P-gp serum levels in comparison with the SS (p < 0.001) and reference (p < 0.001) groups. MIF correlated positively with P-gp (rho = 0.41, p < 0.001). MIF (≥15.75 ng/mL) and P-gp (≥15.22 ng/mL) were a risk factor for SR (OR = 2.29, OR = 5.27). CHAID identified high P-gp as the main risk factor for SR and high MIF as the second risk factor in those patients with low P-gp. Conclusions: An association between MIF and P-gp serum levels was observed in SR. CHAID identified P-gp ≥ 15.22 ng/mL as the main risk factor for SR. More studies are needed to validate these results. MDPI 2022-10-10 /pmc/articles/PMC9573564/ /pubmed/36235275 http://dx.doi.org/10.3390/molecules27196741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Beltrán-Ramírez, Alberto Muñoz-Valle, José Francisco Gamez-Nava, Jorge I. Saldaña-Cruz, Ana Miriam Gonzalez-Lopez, Laura Padilla-Ortega, Alejandro Arias-García, Francisco I. Sánchez-Zuno, Gabriela Athziri Nava-Valdivia, Cesar Arturo Ponce-Guarneros, Juan Manuel García-Galindo, Jesús Jonathan Perez-Guerrero, Edsaúl Emilio Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients |
title | Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients |
title_full | Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients |
title_fullStr | Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients |
title_full_unstemmed | Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients |
title_short | Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients |
title_sort | steroid resistance associated with high mif and p-gp serum levels in sle patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573564/ https://www.ncbi.nlm.nih.gov/pubmed/36235275 http://dx.doi.org/10.3390/molecules27196741 |
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