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Discovery of E3 Ligase Ligands for Target Protein Degradation

Target protein degradation has emerged as a promising strategy for the discovery of novel therapeutics during the last decade. Proteolysis-targeting chimera (PROTAC) harnesses a cellular ubiquitin-dependent proteolysis system for the efficient degradation of a protein of interest. PROTAC consists of...

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Detalles Bibliográficos
Autores principales:	Lee, Jaeseok, Lee, Youngjun, Jung, Young Mee, Park, Ju Hyun, Yoo, Hyuk Sang, Park, Jongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573645/ https://www.ncbi.nlm.nih.gov/pubmed/36235052 http://dx.doi.org/10.3390/molecules27196515

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