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What Has Immunology Brought to Periodontal Disease in Recent Years?

Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged periodontal tissues, new aspects of the destruction mechanism...

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Autores principales: Kowalski, Jan, Nowak, Maciej, Górski, Bartłomiej, Górska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573852/
https://www.ncbi.nlm.nih.gov/pubmed/36245042
http://dx.doi.org/10.1007/s00005-022-00662-9
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author Kowalski, Jan
Nowak, Maciej
Górski, Bartłomiej
Górska, Renata
author_facet Kowalski, Jan
Nowak, Maciej
Górski, Bartłomiej
Górska, Renata
author_sort Kowalski, Jan
collection PubMed
description Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged periodontal tissues, new aspects of the destruction mechanisms are being raised. Among them, the greatest attention is paid to the influence of host response on the clinical manifestations of the disease. Numerous studies have proved that the shift from gingivitis to periodontitis is not a simple progress of the disease, but an event occurring only in susceptible individuals. Susceptibility may result from appearance of local factors facilitating biofilm accumulation and/or maturation, or from systemic features, among which over-reaction and prolonged agitation of non-specific component of inflammatory response is crucial. The present paper summarizes the association between periodontology and immunology and updates the knowledge accrued mostly in the recent years. After a brief explanation of advances in understanding of the disease aetiology, the most studied and potentially viable immunological markers of periodontal disease are presented. Possible new therapeutic strategies, exploiting knowledge about the nature of host response—immunomodulation and reduction of chronic oxidative stress—are also presented.
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spelling pubmed-95738522022-10-18 What Has Immunology Brought to Periodontal Disease in Recent Years? Kowalski, Jan Nowak, Maciej Górski, Bartłomiej Górska, Renata Arch Immunol Ther Exp (Warsz) Review Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged periodontal tissues, new aspects of the destruction mechanisms are being raised. Among them, the greatest attention is paid to the influence of host response on the clinical manifestations of the disease. Numerous studies have proved that the shift from gingivitis to periodontitis is not a simple progress of the disease, but an event occurring only in susceptible individuals. Susceptibility may result from appearance of local factors facilitating biofilm accumulation and/or maturation, or from systemic features, among which over-reaction and prolonged agitation of non-specific component of inflammatory response is crucial. The present paper summarizes the association between periodontology and immunology and updates the knowledge accrued mostly in the recent years. After a brief explanation of advances in understanding of the disease aetiology, the most studied and potentially viable immunological markers of periodontal disease are presented. Possible new therapeutic strategies, exploiting knowledge about the nature of host response—immunomodulation and reduction of chronic oxidative stress—are also presented. Springer International Publishing 2022-10-16 2022 /pmc/articles/PMC9573852/ /pubmed/36245042 http://dx.doi.org/10.1007/s00005-022-00662-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kowalski, Jan
Nowak, Maciej
Górski, Bartłomiej
Górska, Renata
What Has Immunology Brought to Periodontal Disease in Recent Years?
title What Has Immunology Brought to Periodontal Disease in Recent Years?
title_full What Has Immunology Brought to Periodontal Disease in Recent Years?
title_fullStr What Has Immunology Brought to Periodontal Disease in Recent Years?
title_full_unstemmed What Has Immunology Brought to Periodontal Disease in Recent Years?
title_short What Has Immunology Brought to Periodontal Disease in Recent Years?
title_sort what has immunology brought to periodontal disease in recent years?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573852/
https://www.ncbi.nlm.nih.gov/pubmed/36245042
http://dx.doi.org/10.1007/s00005-022-00662-9
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