The ABACHAI clinical trial protocol: Safety and efficacy of abatacept (s.c.) in patients with CTLA-4 insufficiency or LRBA deficiency: A non controlled phase 2 clinical trial

BACKGROUND: Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) insufficiency and lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency are both complex immune dysregulation syndromes with an underlying regulatory T cell dysfunction due to the lack of CTLA-4 protein. As anti...

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Detalles Bibliográficos
Autores principales: Krausz, Máté, Uhlmann, Annette, Rump, Ina Caroline, Ihorst, Gabriele, Goldacker, Sigune, Sogkas, Georgios, Posadas-Cantera, Sara, Schmidt, Reinhold, Feißt, Manuel, Alsina, Laia, Dybedal, Ingunn, Recher, Mike, Warnatz, Klaus, Grimbacher, Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573884/
https://www.ncbi.nlm.nih.gov/pubmed/36262801
http://dx.doi.org/10.1016/j.conctc.2022.101008

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