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Immunization with HIV-1 trimeric SOSIP.664 BG505 or founder virus C (FVC(Env)) covalently complexed to two-domain CD4(S60C) elicits cross-clade neutralizing antibodies in New Zealand white rabbits

Background: An ongoing challenge in HIV-1 vaccine research is finding a novel HIV-1 envelope glycoprotein (Env)-based immunogen that elicits broadly cross-neutralizing antibodies (bnAbs) without requiring complex sequential immunization regimens to drive the required antibody affinity maturation. Pr...

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Detalles Bibliográficos
Autores principales:	Tumba, Nancy L., Owen, Gavin R., Killick, Mark A., Papathanasopoulos, Maria A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Regular paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573916/ https://www.ncbi.nlm.nih.gov/pubmed/36262212 http://dx.doi.org/10.1016/j.jvacx.2022.100222

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