Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice

Activation of T cell responses is essential for effective tumor clearance; however, inducing targeted, potent antigen presentation to stimulate T cell responses remains challenging. We generated Activating Antigen Carriers (AACs) by engineering red blood cells (RBCs) to encapsulate relevant tumor an...

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Detalles Bibliográficos
Autores principales: Blagovic, Katarina, Smith, Carolyne K., Ramakrishnan, Amritha, Moore, Lindsay, Soto, David R., Thompson, Zachary, Stockmann, Adam P., Kruszelnicki, Sonia, Thakkar, Akshi, Murray, Jason, Torres, Sebastian, Wondimagegnhu, Bersabel, Yi, Roslyn, Dadgar, Maisam, Paracha, Abdul M., Page, Claire, Clear, Louise, Chaudhry, Omer A., Myint, Melissa, Bridgen, Devin T., Gilbert, Jonathan B., Seidl, Katherine J., Sharei, Armon, Loughhead, Scott, Bernstein, Howard, Yarar, Defne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573954/
https://www.ncbi.nlm.nih.gov/pubmed/36263022
http://dx.doi.org/10.3389/fimmu.2022.1015585

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