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The potential of functionalized dressing releasing flavonoids facilitates scar-free healing

Scars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kina...

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Autores principales: Zhang, Mengyuan, Chen, Xiaohang, Zhang, Yuan, Zhao, Xiangyu, Zhao, Jing, Wang, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573991/
https://www.ncbi.nlm.nih.gov/pubmed/36262272
http://dx.doi.org/10.3389/fmed.2022.978120
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author Zhang, Mengyuan
Chen, Xiaohang
Zhang, Yuan
Zhao, Xiangyu
Zhao, Jing
Wang, Xing
author_facet Zhang, Mengyuan
Chen, Xiaohang
Zhang, Yuan
Zhao, Xiangyu
Zhao, Jing
Wang, Xing
author_sort Zhang, Mengyuan
collection PubMed
description Scars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kinase, and yes-related transcriptional regulators at infancy or the oral mucosa is thought to be the reason of scarless regenerative capacity after tissue defects. Currently, tissue engineering products for defect repair frequently overlook the management of postoperative scars, and inhibitors of important genes alone have negative consequences for the organism. Natural flavonoids have hemostatic, anti-inflammatory, antioxidant, and antibacterial properties, which promote wound healing and have anti-scar properties by interfering with the transmission of key signaling pathways involved in scar formation. The combination of flavonoid-rich drug dressings provides a platform for clinical translation of compounds that aid in drug disintegration, prolonged release, and targeted delivery. Therefore, we present a review of the mechanisms and effects of flavonoids in promoting scar-free regeneration and the application of flavonoid-laden dressings.
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spelling pubmed-95739912022-10-18 The potential of functionalized dressing releasing flavonoids facilitates scar-free healing Zhang, Mengyuan Chen, Xiaohang Zhang, Yuan Zhao, Xiangyu Zhao, Jing Wang, Xing Front Med (Lausanne) Medicine Scars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kinase, and yes-related transcriptional regulators at infancy or the oral mucosa is thought to be the reason of scarless regenerative capacity after tissue defects. Currently, tissue engineering products for defect repair frequently overlook the management of postoperative scars, and inhibitors of important genes alone have negative consequences for the organism. Natural flavonoids have hemostatic, anti-inflammatory, antioxidant, and antibacterial properties, which promote wound healing and have anti-scar properties by interfering with the transmission of key signaling pathways involved in scar formation. The combination of flavonoid-rich drug dressings provides a platform for clinical translation of compounds that aid in drug disintegration, prolonged release, and targeted delivery. Therefore, we present a review of the mechanisms and effects of flavonoids in promoting scar-free regeneration and the application of flavonoid-laden dressings. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9573991/ /pubmed/36262272 http://dx.doi.org/10.3389/fmed.2022.978120 Text en Copyright © 2022 Zhang, Chen, Zhang, Zhao, Zhao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Mengyuan
Chen, Xiaohang
Zhang, Yuan
Zhao, Xiangyu
Zhao, Jing
Wang, Xing
The potential of functionalized dressing releasing flavonoids facilitates scar-free healing
title The potential of functionalized dressing releasing flavonoids facilitates scar-free healing
title_full The potential of functionalized dressing releasing flavonoids facilitates scar-free healing
title_fullStr The potential of functionalized dressing releasing flavonoids facilitates scar-free healing
title_full_unstemmed The potential of functionalized dressing releasing flavonoids facilitates scar-free healing
title_short The potential of functionalized dressing releasing flavonoids facilitates scar-free healing
title_sort potential of functionalized dressing releasing flavonoids facilitates scar-free healing
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9573991/
https://www.ncbi.nlm.nih.gov/pubmed/36262272
http://dx.doi.org/10.3389/fmed.2022.978120
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