Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination

Long noncoding RNAs (lncRNAs), which lack protein-coding ability, can regulate cancer cell growth, proliferation, invasion, and metastasis. Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment that have a significant impact on cancer progression. Small extracellular v...

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Autores principales: Zhang, Li-jie, Chen, Feng, Liang, Xiao-ru, Ponnusamy, Murugavel, Qin, Hao, Lin, Zhi-juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574020/
https://www.ncbi.nlm.nih.gov/pubmed/36263199
http://dx.doi.org/10.3389/fonc.2022.1008856
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author Zhang, Li-jie
Chen, Feng
Liang, Xiao-ru
Ponnusamy, Murugavel
Qin, Hao
Lin, Zhi-juan
author_facet Zhang, Li-jie
Chen, Feng
Liang, Xiao-ru
Ponnusamy, Murugavel
Qin, Hao
Lin, Zhi-juan
author_sort Zhang, Li-jie
collection PubMed
description Long noncoding RNAs (lncRNAs), which lack protein-coding ability, can regulate cancer cell growth, proliferation, invasion, and metastasis. Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment that have a significant impact on cancer progression. Small extracellular vesicles (sEV) are crucial mediators of intercellular communications. Cancer cell and macrophage-derived sEV can carry lncRNAs that influence the onset and progression of cancer. Dysregulation of lncRNAs, TAMs, and sEV is widely observed in tumors which makes them valuable targets for cancer immunotherapy. In this review, we summarize current updates on the interactions among sEV, lncRNAs, and TAMs in tumors and provide new perspectives on cancer diagnosis and treatment.
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spelling pubmed-95740202022-10-18 Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination Zhang, Li-jie Chen, Feng Liang, Xiao-ru Ponnusamy, Murugavel Qin, Hao Lin, Zhi-juan Front Oncol Oncology Long noncoding RNAs (lncRNAs), which lack protein-coding ability, can regulate cancer cell growth, proliferation, invasion, and metastasis. Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment that have a significant impact on cancer progression. Small extracellular vesicles (sEV) are crucial mediators of intercellular communications. Cancer cell and macrophage-derived sEV can carry lncRNAs that influence the onset and progression of cancer. Dysregulation of lncRNAs, TAMs, and sEV is widely observed in tumors which makes them valuable targets for cancer immunotherapy. In this review, we summarize current updates on the interactions among sEV, lncRNAs, and TAMs in tumors and provide new perspectives on cancer diagnosis and treatment. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9574020/ /pubmed/36263199 http://dx.doi.org/10.3389/fonc.2022.1008856 Text en Copyright © 2022 Zhang, Chen, Liang, Ponnusamy, Qin and Lin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Li-jie
Chen, Feng
Liang, Xiao-ru
Ponnusamy, Murugavel
Qin, Hao
Lin, Zhi-juan
Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination
title Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination
title_full Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination
title_fullStr Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination
title_full_unstemmed Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination
title_short Crosstalk among long non-coding RNA, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination
title_sort crosstalk among long non-coding rna, tumor-associated macrophages and small extracellular vesicles in tumorigenesis and dissemination
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574020/
https://www.ncbi.nlm.nih.gov/pubmed/36263199
http://dx.doi.org/10.3389/fonc.2022.1008856
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