Cargando…

Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex

Discrimination of cues predicting non-nociceptive/nociceptive stimuli is essential for predicting whether a non-painful or painful stimulus will be administered and for eliciting placebo/nocebo (pain reduction/pain enhancement) effects. Dysfunction of the neural system involved in placebo effects ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwama, Yudai, Takamoto, Kouichi, Hibi, Daisuke, Nishimaru, Hiroshi, Matsumoto, Jumpei, Setogawa, Tsuyoshi, Nishijo, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574021/
https://www.ncbi.nlm.nih.gov/pubmed/36263366
http://dx.doi.org/10.3389/fnins.2022.1001177
_version_ 1784811009330905088
author Iwama, Yudai
Takamoto, Kouichi
Hibi, Daisuke
Nishimaru, Hiroshi
Matsumoto, Jumpei
Setogawa, Tsuyoshi
Nishijo, Hisao
author_facet Iwama, Yudai
Takamoto, Kouichi
Hibi, Daisuke
Nishimaru, Hiroshi
Matsumoto, Jumpei
Setogawa, Tsuyoshi
Nishijo, Hisao
author_sort Iwama, Yudai
collection PubMed
description Discrimination of cues predicting non-nociceptive/nociceptive stimuli is essential for predicting whether a non-painful or painful stimulus will be administered and for eliciting placebo/nocebo (pain reduction/pain enhancement) effects. Dysfunction of the neural system involved in placebo effects has been implicated in the pathology of chronic pain, while female sex is one of the important risk factors for development of chronic pain in young adults. The dorsolateral prefrontal cortex (dl-PFC) is suggested to be involved in placebo effects and is sensitive to sex and age. In this study, to examine the neural mechanisms by which sex and age alter placebo and nocebo effects, we analyzed cerebral hemodynamic activities in the dl-PFC in different sex and age groups during a differential conditioning task. During the training session, two different sounds were followed by low- and high-intensity electrical shocks. In the following recording session, electrical shocks, the intensity of which was mismatched to the sounds, were occasionally administered to elicit placebo and nocebo effects. In young female participants, both placebo effects and hemodynamic responses to the conditioned sounds in the right dl-PFC were significantly lower than those in elderly female participants, while there were no age differences in male participants. The hemodynamic responses to the sound paired with the safe stimulus in the right dl-PFC were significantly correlated with placebo effects, except in the young female group. These results suggest that blunted placebo effects in the young female participants are ascribed to blunted responses to the sound associated with the safe stimulus in the right dl-PFC, and that sex- and age-related factors may alter the responsiveness of the right dl-PFC to associative cues predicting a safe stimulus.
format Online
Article
Text
id pubmed-9574021
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95740212022-10-18 Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex Iwama, Yudai Takamoto, Kouichi Hibi, Daisuke Nishimaru, Hiroshi Matsumoto, Jumpei Setogawa, Tsuyoshi Nishijo, Hisao Front Neurosci Neuroscience Discrimination of cues predicting non-nociceptive/nociceptive stimuli is essential for predicting whether a non-painful or painful stimulus will be administered and for eliciting placebo/nocebo (pain reduction/pain enhancement) effects. Dysfunction of the neural system involved in placebo effects has been implicated in the pathology of chronic pain, while female sex is one of the important risk factors for development of chronic pain in young adults. The dorsolateral prefrontal cortex (dl-PFC) is suggested to be involved in placebo effects and is sensitive to sex and age. In this study, to examine the neural mechanisms by which sex and age alter placebo and nocebo effects, we analyzed cerebral hemodynamic activities in the dl-PFC in different sex and age groups during a differential conditioning task. During the training session, two different sounds were followed by low- and high-intensity electrical shocks. In the following recording session, electrical shocks, the intensity of which was mismatched to the sounds, were occasionally administered to elicit placebo and nocebo effects. In young female participants, both placebo effects and hemodynamic responses to the conditioned sounds in the right dl-PFC were significantly lower than those in elderly female participants, while there were no age differences in male participants. The hemodynamic responses to the sound paired with the safe stimulus in the right dl-PFC were significantly correlated with placebo effects, except in the young female group. These results suggest that blunted placebo effects in the young female participants are ascribed to blunted responses to the sound associated with the safe stimulus in the right dl-PFC, and that sex- and age-related factors may alter the responsiveness of the right dl-PFC to associative cues predicting a safe stimulus. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9574021/ /pubmed/36263366 http://dx.doi.org/10.3389/fnins.2022.1001177 Text en Copyright © 2022 Iwama, Takamoto, Hibi, Nishimaru, Matsumoto, Setogawa and Nishijo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Iwama, Yudai
Takamoto, Kouichi
Hibi, Daisuke
Nishimaru, Hiroshi
Matsumoto, Jumpei
Setogawa, Tsuyoshi
Nishijo, Hisao
Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex
title Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex
title_full Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex
title_fullStr Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex
title_full_unstemmed Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex
title_short Young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex
title_sort young female participants show blunted placebo effects associated with blunted responses to a cue predicting a safe stimulus in the right dorsolateral prefrontal cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574021/
https://www.ncbi.nlm.nih.gov/pubmed/36263366
http://dx.doi.org/10.3389/fnins.2022.1001177
work_keys_str_mv AT iwamayudai youngfemaleparticipantsshowbluntedplaceboeffectsassociatedwithbluntedresponsestoacuepredictingasafestimulusintherightdorsolateralprefrontalcortex
AT takamotokouichi youngfemaleparticipantsshowbluntedplaceboeffectsassociatedwithbluntedresponsestoacuepredictingasafestimulusintherightdorsolateralprefrontalcortex
AT hibidaisuke youngfemaleparticipantsshowbluntedplaceboeffectsassociatedwithbluntedresponsestoacuepredictingasafestimulusintherightdorsolateralprefrontalcortex
AT nishimaruhiroshi youngfemaleparticipantsshowbluntedplaceboeffectsassociatedwithbluntedresponsestoacuepredictingasafestimulusintherightdorsolateralprefrontalcortex
AT matsumotojumpei youngfemaleparticipantsshowbluntedplaceboeffectsassociatedwithbluntedresponsestoacuepredictingasafestimulusintherightdorsolateralprefrontalcortex
AT setogawatsuyoshi youngfemaleparticipantsshowbluntedplaceboeffectsassociatedwithbluntedresponsestoacuepredictingasafestimulusintherightdorsolateralprefrontalcortex
AT nishijohisao youngfemaleparticipantsshowbluntedplaceboeffectsassociatedwithbluntedresponsestoacuepredictingasafestimulusintherightdorsolateralprefrontalcortex