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Targeting phase separation on enhancers induced by transcription factor complex formations as a new strategy for treating drug-resistant cancers
The limited options for treating patients with drug-resistant cancers have emphasized the need to identify alternative treatment targets. Tumor cells have large super-enhancers (SEs) in the vicinity of important oncogenes for activation. The physical process of liquid-liquid phase separation (LLPS)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574090/ https://www.ncbi.nlm.nih.gov/pubmed/36263200 http://dx.doi.org/10.3389/fonc.2022.1024600 |