The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Rec...

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Autores principales: Zhao, Hanxiao, Li, Li, Zhao, Ning, Lu, Aiping, Lu, Cheng, He, Xiaojuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574091/
https://www.ncbi.nlm.nih.gov/pubmed/36263019
http://dx.doi.org/10.3389/fcell.2022.1011371
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author Zhao, Hanxiao
Li, Li
Zhao, Ning
Lu, Aiping
Lu, Cheng
He, Xiaojuan
author_facet Zhao, Hanxiao
Li, Li
Zhao, Ning
Lu, Aiping
Lu, Cheng
He, Xiaojuan
author_sort Zhao, Hanxiao
collection PubMed
description Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.
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spelling pubmed-95740912022-10-18 The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis Zhao, Hanxiao Li, Li Zhao, Ning Lu, Aiping Lu, Cheng He, Xiaojuan Front Cell Dev Biol Cell and Developmental Biology Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9574091/ /pubmed/36263019 http://dx.doi.org/10.3389/fcell.2022.1011371 Text en Copyright © 2022 Zhao, Li, Zhao, Lu, Lu and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhao, Hanxiao
Li, Li
Zhao, Ning
Lu, Aiping
Lu, Cheng
He, Xiaojuan
The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis
title The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis
title_full The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis
title_fullStr The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis
title_full_unstemmed The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis
title_short The effect of long non-coding RNAs in joint destruction of rheumatoid arthritis
title_sort effect of long non-coding rnas in joint destruction of rheumatoid arthritis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574091/
https://www.ncbi.nlm.nih.gov/pubmed/36263019
http://dx.doi.org/10.3389/fcell.2022.1011371
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