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Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI
Despite extensive studies detecting laminar functional magnetic resonance imaging (fMRI) signals to illustrate the canonical microcircuit, the spatiotemporal characteristics of laminar-specific information flow across cortical regions remain to be fully investigated in both evoked and resting condit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574235/ https://www.ncbi.nlm.nih.gov/pubmed/35107125 http://dx.doi.org/10.1093/cercor/bhab497 |
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author | Choi, Sangcheon Zeng, Hang Chen, Yi Sobczak, Filip Qian, Chunqi Yu, Xin |
author_facet | Choi, Sangcheon Zeng, Hang Chen, Yi Sobczak, Filip Qian, Chunqi Yu, Xin |
author_sort | Choi, Sangcheon |
collection | PubMed |
description | Despite extensive studies detecting laminar functional magnetic resonance imaging (fMRI) signals to illustrate the canonical microcircuit, the spatiotemporal characteristics of laminar-specific information flow across cortical regions remain to be fully investigated in both evoked and resting conditions at different brain states. Here, we developed a multislice line-scanning fMRI (MS-LS) method to detect laminar fMRI signals in adjacent cortical regions with high spatial (50 μm) and temporal resolution (100 ms) in anesthetized rats. Across different trials, we detected either laminar-specific positive or negative blood-oxygen-level-dependent (BOLD) responses in the surrounding cortical region adjacent to the most activated cortex under the evoked condition. Specifically, in contrast to typical Layer (L) 4 correlation across different regions due to the thalamocortical projections for trials with positive BOLD, a strong correlation pattern specific in L2/3 was detected for trials with negative BOLD in adjacent regions, which indicated brain state-dependent laminar-fMRI responses based on corticocortical interaction. Also, in resting-state (rs-) fMRI study, robust lag time differences in L2/3, 4, and 5 across multiple cortices represented the low-frequency rs-fMRI signal propagation from caudal to rostral slices. In summary, our study provided a unique laminar fMRI mapping scheme to better characterize trial-specific intra- and inter-laminar functional connectivity in evoked and resting-state MS-LS. |
format | Online Article Text |
id | pubmed-9574235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95742352022-10-19 Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI Choi, Sangcheon Zeng, Hang Chen, Yi Sobczak, Filip Qian, Chunqi Yu, Xin Cereb Cortex Original Article Despite extensive studies detecting laminar functional magnetic resonance imaging (fMRI) signals to illustrate the canonical microcircuit, the spatiotemporal characteristics of laminar-specific information flow across cortical regions remain to be fully investigated in both evoked and resting conditions at different brain states. Here, we developed a multislice line-scanning fMRI (MS-LS) method to detect laminar fMRI signals in adjacent cortical regions with high spatial (50 μm) and temporal resolution (100 ms) in anesthetized rats. Across different trials, we detected either laminar-specific positive or negative blood-oxygen-level-dependent (BOLD) responses in the surrounding cortical region adjacent to the most activated cortex under the evoked condition. Specifically, in contrast to typical Layer (L) 4 correlation across different regions due to the thalamocortical projections for trials with positive BOLD, a strong correlation pattern specific in L2/3 was detected for trials with negative BOLD in adjacent regions, which indicated brain state-dependent laminar-fMRI responses based on corticocortical interaction. Also, in resting-state (rs-) fMRI study, robust lag time differences in L2/3, 4, and 5 across multiple cortices represented the low-frequency rs-fMRI signal propagation from caudal to rostral slices. In summary, our study provided a unique laminar fMRI mapping scheme to better characterize trial-specific intra- and inter-laminar functional connectivity in evoked and resting-state MS-LS. Oxford University Press 2022-02-02 /pmc/articles/PMC9574235/ /pubmed/35107125 http://dx.doi.org/10.1093/cercor/bhab497 Text en © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Choi, Sangcheon Zeng, Hang Chen, Yi Sobczak, Filip Qian, Chunqi Yu, Xin Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI |
title | Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI |
title_full | Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI |
title_fullStr | Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI |
title_full_unstemmed | Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI |
title_short | Laminar-specific functional connectivity mapping with multi-slice line-scanning fMRI |
title_sort | laminar-specific functional connectivity mapping with multi-slice line-scanning fmri |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574235/ https://www.ncbi.nlm.nih.gov/pubmed/35107125 http://dx.doi.org/10.1093/cercor/bhab497 |
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