The Mechanisms of Action of Tumor Treating Fields

Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic...

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Autores principales: Moser, Justin C., Salvador, Ellaine, Deniz, Karina, Swanson, Kenneth, Tuszynski, Jack, Carlson, Kristen W., Karanam, Narasimha Kumar, Patel, Chirag B., Story, Michael, Lou, Emil, Hagemann, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574373/
https://www.ncbi.nlm.nih.gov/pubmed/35839284
http://dx.doi.org/10.1158/0008-5472.CAN-22-0887
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author Moser, Justin C.
Salvador, Ellaine
Deniz, Karina
Swanson, Kenneth
Tuszynski, Jack
Carlson, Kristen W.
Karanam, Narasimha Kumar
Patel, Chirag B.
Story, Michael
Lou, Emil
Hagemann, Carsten
author_facet Moser, Justin C.
Salvador, Ellaine
Deniz, Karina
Swanson, Kenneth
Tuszynski, Jack
Carlson, Kristen W.
Karanam, Narasimha Kumar
Patel, Chirag B.
Story, Michael
Lou, Emil
Hagemann, Carsten
author_sort Moser, Justin C.
collection PubMed
description Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.
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spelling pubmed-95743732023-01-05 The Mechanisms of Action of Tumor Treating Fields Moser, Justin C. Salvador, Ellaine Deniz, Karina Swanson, Kenneth Tuszynski, Jack Carlson, Kristen W. Karanam, Narasimha Kumar Patel, Chirag B. Story, Michael Lou, Emil Hagemann, Carsten Cancer Res Reviews Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action. American Association for Cancer Research 2022-10-17 2022-07-15 /pmc/articles/PMC9574373/ /pubmed/35839284 http://dx.doi.org/10.1158/0008-5472.CAN-22-0887 Text en ©2022 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle Reviews
Moser, Justin C.
Salvador, Ellaine
Deniz, Karina
Swanson, Kenneth
Tuszynski, Jack
Carlson, Kristen W.
Karanam, Narasimha Kumar
Patel, Chirag B.
Story, Michael
Lou, Emil
Hagemann, Carsten
The Mechanisms of Action of Tumor Treating Fields
title The Mechanisms of Action of Tumor Treating Fields
title_full The Mechanisms of Action of Tumor Treating Fields
title_fullStr The Mechanisms of Action of Tumor Treating Fields
title_full_unstemmed The Mechanisms of Action of Tumor Treating Fields
title_short The Mechanisms of Action of Tumor Treating Fields
title_sort mechanisms of action of tumor treating fields
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574373/
https://www.ncbi.nlm.nih.gov/pubmed/35839284
http://dx.doi.org/10.1158/0008-5472.CAN-22-0887
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