Boosting Antitumor Immunity with an Expanded Neoepitope Landscape

Immune-checkpoint blockade therapy has been successfully applied to many cancers, particularly tumors that harbor a high mutational burden and consequently express a high abundance of neoantigens. However, novel approaches are needed to improve the efficacy of immunotherapy for treating tumors that...

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Detalles Bibliográficos
Autores principales: Nagel, Remco, Pataskar, Abhijeet, Champagne, Julien, Agami, Reuven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574376/
https://www.ncbi.nlm.nih.gov/pubmed/35904353
http://dx.doi.org/10.1158/0008-5472.CAN-22-1525
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author Nagel, Remco
Pataskar, Abhijeet
Champagne, Julien
Agami, Reuven
author_facet Nagel, Remco
Pataskar, Abhijeet
Champagne, Julien
Agami, Reuven
author_sort Nagel, Remco
collection PubMed
description Immune-checkpoint blockade therapy has been successfully applied to many cancers, particularly tumors that harbor a high mutational burden and consequently express a high abundance of neoantigens. However, novel approaches are needed to improve the efficacy of immunotherapy for treating tumors that lack a high load of classic genetically derived neoantigens. Recent discoveries of broad classes of nongenetically encoded and inducible neoepitopes open up new avenues for therapeutic development to enhance sensitivity to immunotherapies. In this review, we discuss recent work on neoantigen discovery, with an emphasis on novel classes of noncanonical neoepitopes.
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spelling pubmed-95743762023-01-05 Boosting Antitumor Immunity with an Expanded Neoepitope Landscape Nagel, Remco Pataskar, Abhijeet Champagne, Julien Agami, Reuven Cancer Res Reviews Immune-checkpoint blockade therapy has been successfully applied to many cancers, particularly tumors that harbor a high mutational burden and consequently express a high abundance of neoantigens. However, novel approaches are needed to improve the efficacy of immunotherapy for treating tumors that lack a high load of classic genetically derived neoantigens. Recent discoveries of broad classes of nongenetically encoded and inducible neoepitopes open up new avenues for therapeutic development to enhance sensitivity to immunotherapies. In this review, we discuss recent work on neoantigen discovery, with an emphasis on novel classes of noncanonical neoepitopes. American Association for Cancer Research 2022-10-17 2022-07-29 /pmc/articles/PMC9574376/ /pubmed/35904353 http://dx.doi.org/10.1158/0008-5472.CAN-22-1525 Text en ©2022 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle Reviews
Nagel, Remco
Pataskar, Abhijeet
Champagne, Julien
Agami, Reuven
Boosting Antitumor Immunity with an Expanded Neoepitope Landscape
title Boosting Antitumor Immunity with an Expanded Neoepitope Landscape
title_full Boosting Antitumor Immunity with an Expanded Neoepitope Landscape
title_fullStr Boosting Antitumor Immunity with an Expanded Neoepitope Landscape
title_full_unstemmed Boosting Antitumor Immunity with an Expanded Neoepitope Landscape
title_short Boosting Antitumor Immunity with an Expanded Neoepitope Landscape
title_sort boosting antitumor immunity with an expanded neoepitope landscape
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574376/
https://www.ncbi.nlm.nih.gov/pubmed/35904353
http://dx.doi.org/10.1158/0008-5472.CAN-22-1525
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AT agamireuven boostingantitumorimmunitywithanexpandedneoepitopelandscape

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