Cargando…
Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study
BACKGROUND: Metabolic syndrome (MetS) and its components have been shown as risk factors for several solid cancers. However, current epidemiological evidence about the relevance of MetS and bladder cancer risk was limited. METHODS: We conducted a prospective cohort study of 476,986 participants with...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574437/ https://www.ncbi.nlm.nih.gov/pubmed/36263231 http://dx.doi.org/10.3389/fonc.2022.996440 |
_version_ | 1784811105842888704 |
---|---|
author | Fang, Shuo Liu, Yuchen Dai, Huiru Gao, Tianshun Zeng, Leli Sun, Rui Zheng, Zilong Yuan, Jinqiu Xia, Bin Pan, Yihang |
author_facet | Fang, Shuo Liu, Yuchen Dai, Huiru Gao, Tianshun Zeng, Leli Sun, Rui Zheng, Zilong Yuan, Jinqiu Xia, Bin Pan, Yihang |
author_sort | Fang, Shuo |
collection | PubMed |
description | BACKGROUND: Metabolic syndrome (MetS) and its components have been shown as risk factors for several solid cancers. However, current epidemiological evidence about the relevance of MetS and bladder cancer risk was limited. METHODS: We conducted a prospective cohort study of 476,986 participants with undiagnosed bladder cancer based on the UK Biobank. MetS was defined as the presence of at least three of the five selected indicators: hypertension, central obesity, raised triglyceride, reduced HDL-cholesterol, and raised fasting plasma glucose. Bladder cancer has been identified through contact with the British Cancer Registry (median follow-up time: 6.6 years). We assessed hazard ratio (HR) and 95% confidence interval (CI) through Cox proportional hazard regression after adjusting for demographic and lifestyle factors. Non-linear associations for individual MetS components were assessed by the restricted cubic spline method. RESULTS: During a follow-up of 3,112,566 person-years, 487 cases of bladder cancer were ascertained. MetS (HR = 1.32, 95% CI = 1.08–1.61), central obesity (HR = 1.39, 95% CI = 1.15–1.68), dyslipidemia for HDL cholesterol (HR = 1.31, 95% CI = 1.04–1.66), and hyperglycemia (HR = 1.44, 95% CI = 1.16–1.79) were associated with elevated risk of bladder cancer. Bladder cancer risk increased with the number of MetS components. In stratified analyses, MetS showed similar effects in bladder cancer independently with sex, age, cigarette and alcohol use, physical activity, and dietary factors. Higher waist circumference, BMI, fasting blood glucose, and glycosylated hemoglobin were independently associated with increased risk of bladder cancer, with no evidence against non-linearity. CONCLUSION: MetS might be an independent risk factor for bladder cancer. Our findings highlighted the importance of individualized management of MetS components for preventing bladder cancer. |
format | Online Article Text |
id | pubmed-9574437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95744372022-10-18 Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study Fang, Shuo Liu, Yuchen Dai, Huiru Gao, Tianshun Zeng, Leli Sun, Rui Zheng, Zilong Yuan, Jinqiu Xia, Bin Pan, Yihang Front Oncol Oncology BACKGROUND: Metabolic syndrome (MetS) and its components have been shown as risk factors for several solid cancers. However, current epidemiological evidence about the relevance of MetS and bladder cancer risk was limited. METHODS: We conducted a prospective cohort study of 476,986 participants with undiagnosed bladder cancer based on the UK Biobank. MetS was defined as the presence of at least three of the five selected indicators: hypertension, central obesity, raised triglyceride, reduced HDL-cholesterol, and raised fasting plasma glucose. Bladder cancer has been identified through contact with the British Cancer Registry (median follow-up time: 6.6 years). We assessed hazard ratio (HR) and 95% confidence interval (CI) through Cox proportional hazard regression after adjusting for demographic and lifestyle factors. Non-linear associations for individual MetS components were assessed by the restricted cubic spline method. RESULTS: During a follow-up of 3,112,566 person-years, 487 cases of bladder cancer were ascertained. MetS (HR = 1.32, 95% CI = 1.08–1.61), central obesity (HR = 1.39, 95% CI = 1.15–1.68), dyslipidemia for HDL cholesterol (HR = 1.31, 95% CI = 1.04–1.66), and hyperglycemia (HR = 1.44, 95% CI = 1.16–1.79) were associated with elevated risk of bladder cancer. Bladder cancer risk increased with the number of MetS components. In stratified analyses, MetS showed similar effects in bladder cancer independently with sex, age, cigarette and alcohol use, physical activity, and dietary factors. Higher waist circumference, BMI, fasting blood glucose, and glycosylated hemoglobin were independently associated with increased risk of bladder cancer, with no evidence against non-linearity. CONCLUSION: MetS might be an independent risk factor for bladder cancer. Our findings highlighted the importance of individualized management of MetS components for preventing bladder cancer. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9574437/ /pubmed/36263231 http://dx.doi.org/10.3389/fonc.2022.996440 Text en Copyright © 2022 Fang, Liu, Dai, Gao, Zeng, Sun, Zheng, Yuan, Xia and Pan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Fang, Shuo Liu, Yuchen Dai, Huiru Gao, Tianshun Zeng, Leli Sun, Rui Zheng, Zilong Yuan, Jinqiu Xia, Bin Pan, Yihang Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study |
title | Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study |
title_full | Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study |
title_fullStr | Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study |
title_full_unstemmed | Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study |
title_short | Association of metabolic syndrome and the risk of bladder cancer: A prospective cohort study |
title_sort | association of metabolic syndrome and the risk of bladder cancer: a prospective cohort study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574437/ https://www.ncbi.nlm.nih.gov/pubmed/36263231 http://dx.doi.org/10.3389/fonc.2022.996440 |
work_keys_str_mv | AT fangshuo associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT liuyuchen associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT daihuiru associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT gaotianshun associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT zengleli associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT sunrui associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT zhengzilong associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT yuanjinqiu associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT xiabin associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy AT panyihang associationofmetabolicsyndromeandtheriskofbladdercanceraprospectivecohortstudy |