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Emerging role of IκBζ in inflammation: Emphasis on psoriasis

Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL‐23 induced Th‐17 differentiation. IkappaB‐Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family members, it...

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Autores principales: Gautam, Preeti, Maenner, Sylvain, Cailotto, Frédéric, Reboul, Pascal, Labialle, Stéphane, Jouzeau, Jean‐Yves, Bourgaud, Frédéric, Moulin, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574490/
https://www.ncbi.nlm.nih.gov/pubmed/36245291
http://dx.doi.org/10.1002/ctm2.1032
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author Gautam, Preeti
Maenner, Sylvain
Cailotto, Frédéric
Reboul, Pascal
Labialle, Stéphane
Jouzeau, Jean‐Yves
Bourgaud, Frédéric
Moulin, David
author_facet Gautam, Preeti
Maenner, Sylvain
Cailotto, Frédéric
Reboul, Pascal
Labialle, Stéphane
Jouzeau, Jean‐Yves
Bourgaud, Frédéric
Moulin, David
author_sort Gautam, Preeti
collection PubMed
description Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL‐23 induced Th‐17 differentiation. IkappaB‐Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family members, it positively regulates NF‐κB pathway by being exclusively localized into the nucleus. IκBζ deficiency reduces visible manifestations of experimental psoriasis by diminishing expression of psoriasis‐associated genes. It is thus tempting to consider IκBζ as a potential therapeutic target for psoriasis as well as for other IL23/IL17‐mediated inflammatory diseases. In this review, we will discuss the regulation of expression of NFKBIZ and its protein IκBζ, its downstream targets, its involvement in pathogenesis of multiple disorders with emphasis on psoriasis and evidences supporting that inhibition of IκBζ may be a promising alternative to current therapeutic managements of psoriasis.
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spelling pubmed-95744902022-10-17 Emerging role of IκBζ in inflammation: Emphasis on psoriasis Gautam, Preeti Maenner, Sylvain Cailotto, Frédéric Reboul, Pascal Labialle, Stéphane Jouzeau, Jean‐Yves Bourgaud, Frédéric Moulin, David Clin Transl Med Reviews Psoriasis is a chronic inflammatory disorder affecting skin and joints that results from immunological dysfunction such as enhanced IL‐23 induced Th‐17 differentiation. IkappaB‐Zeta (IκBζ) is an atypical transcriptional factor of the IκB protein family since, contrary to the other family members, it positively regulates NF‐κB pathway by being exclusively localized into the nucleus. IκBζ deficiency reduces visible manifestations of experimental psoriasis by diminishing expression of psoriasis‐associated genes. It is thus tempting to consider IκBζ as a potential therapeutic target for psoriasis as well as for other IL23/IL17‐mediated inflammatory diseases. In this review, we will discuss the regulation of expression of NFKBIZ and its protein IκBζ, its downstream targets, its involvement in pathogenesis of multiple disorders with emphasis on psoriasis and evidences supporting that inhibition of IκBζ may be a promising alternative to current therapeutic managements of psoriasis. John Wiley and Sons Inc. 2022-10-17 /pmc/articles/PMC9574490/ /pubmed/36245291 http://dx.doi.org/10.1002/ctm2.1032 Text en © 2022 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Gautam, Preeti
Maenner, Sylvain
Cailotto, Frédéric
Reboul, Pascal
Labialle, Stéphane
Jouzeau, Jean‐Yves
Bourgaud, Frédéric
Moulin, David
Emerging role of IκBζ in inflammation: Emphasis on psoriasis
title Emerging role of IκBζ in inflammation: Emphasis on psoriasis
title_full Emerging role of IκBζ in inflammation: Emphasis on psoriasis
title_fullStr Emerging role of IκBζ in inflammation: Emphasis on psoriasis
title_full_unstemmed Emerging role of IκBζ in inflammation: Emphasis on psoriasis
title_short Emerging role of IκBζ in inflammation: Emphasis on psoriasis
title_sort emerging role of iκbζ in inflammation: emphasis on psoriasis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574490/
https://www.ncbi.nlm.nih.gov/pubmed/36245291
http://dx.doi.org/10.1002/ctm2.1032
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