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The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites

Magnetic resonance imaging-guided focused ultrasound combined with microbubbles injected in the bloodstream (MRIgFUS) temporarily increases the permeability of the blood-brain barrier (BBB), which facilitates the entry of intravenously administered adeno-associated viruses (AAVs) from the blood to t...

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Detalles Bibliográficos
Autores principales:	Kofoed, Rikke Hahn, Noseworthy, Kate, Wu, Kathleen, Sivadas, Shuruthisai, Stanek, Lisa, Elmer, Bradford, Hynynen, Kullervo, Shihabuddin, Lamya S., Aubert, Isabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574578/ https://www.ncbi.nlm.nih.gov/pubmed/36284767 http://dx.doi.org/10.1016/j.omtm.2022.09.011

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