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Evolutionary divergence of embryo implantation in primates

Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early implantation stages. Non-human primates recapitulate many aspects of human embryo devel...

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Detalles Bibliográficos
Autores principales: Siriwardena, Dylan, Boroviak, Thorsten E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574630/
https://www.ncbi.nlm.nih.gov/pubmed/36252209
http://dx.doi.org/10.1098/rstb.2021.0256
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author Siriwardena, Dylan
Boroviak, Thorsten E.
author_facet Siriwardena, Dylan
Boroviak, Thorsten E.
author_sort Siriwardena, Dylan
collection PubMed
description Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early implantation stages. Non-human primates recapitulate many aspects of human embryo development and provide crucial insights into trophoblast development, uterine receptivity and embryo invasion. Moreover, primate species exhibit a variety of implantation strategies and differ in embryo invasion depths. This review examines conservation and divergence of the key processes required for embryo implantation in different primates and in comparison with the canonical rodent model. We discuss trophectoderm compartmentalization, endometrial remodelling and embryo adhesion and invasion. Finally, we propose that studying the mechanism controlling invasion depth between different primate species may provide new insights and treatment strategies for placentation disorders in humans. This article is part of the theme issue ‘Extraembryonic tissues: exploring concepts, definitions and functions across the animal kingdom’.
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spelling pubmed-95746302022-10-28 Evolutionary divergence of embryo implantation in primates Siriwardena, Dylan Boroviak, Thorsten E. Philos Trans R Soc Lond B Biol Sci Articles Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early implantation stages. Non-human primates recapitulate many aspects of human embryo development and provide crucial insights into trophoblast development, uterine receptivity and embryo invasion. Moreover, primate species exhibit a variety of implantation strategies and differ in embryo invasion depths. This review examines conservation and divergence of the key processes required for embryo implantation in different primates and in comparison with the canonical rodent model. We discuss trophectoderm compartmentalization, endometrial remodelling and embryo adhesion and invasion. Finally, we propose that studying the mechanism controlling invasion depth between different primate species may provide new insights and treatment strategies for placentation disorders in humans. This article is part of the theme issue ‘Extraembryonic tissues: exploring concepts, definitions and functions across the animal kingdom’. The Royal Society 2022-12-05 2022-10-17 /pmc/articles/PMC9574630/ /pubmed/36252209 http://dx.doi.org/10.1098/rstb.2021.0256 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Siriwardena, Dylan
Boroviak, Thorsten E.
Evolutionary divergence of embryo implantation in primates
title Evolutionary divergence of embryo implantation in primates
title_full Evolutionary divergence of embryo implantation in primates
title_fullStr Evolutionary divergence of embryo implantation in primates
title_full_unstemmed Evolutionary divergence of embryo implantation in primates
title_short Evolutionary divergence of embryo implantation in primates
title_sort evolutionary divergence of embryo implantation in primates
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574630/
https://www.ncbi.nlm.nih.gov/pubmed/36252209
http://dx.doi.org/10.1098/rstb.2021.0256
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