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Evolutionary divergence of embryo implantation in primates
Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early implantation stages. Non-human primates recapitulate many aspects of human embryo devel...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574630/ https://www.ncbi.nlm.nih.gov/pubmed/36252209 http://dx.doi.org/10.1098/rstb.2021.0256 |
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author | Siriwardena, Dylan Boroviak, Thorsten E. |
author_facet | Siriwardena, Dylan Boroviak, Thorsten E. |
author_sort | Siriwardena, Dylan |
collection | PubMed |
description | Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early implantation stages. Non-human primates recapitulate many aspects of human embryo development and provide crucial insights into trophoblast development, uterine receptivity and embryo invasion. Moreover, primate species exhibit a variety of implantation strategies and differ in embryo invasion depths. This review examines conservation and divergence of the key processes required for embryo implantation in different primates and in comparison with the canonical rodent model. We discuss trophectoderm compartmentalization, endometrial remodelling and embryo adhesion and invasion. Finally, we propose that studying the mechanism controlling invasion depth between different primate species may provide new insights and treatment strategies for placentation disorders in humans. This article is part of the theme issue ‘Extraembryonic tissues: exploring concepts, definitions and functions across the animal kingdom’. |
format | Online Article Text |
id | pubmed-9574630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-95746302022-10-28 Evolutionary divergence of embryo implantation in primates Siriwardena, Dylan Boroviak, Thorsten E. Philos Trans R Soc Lond B Biol Sci Articles Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early implantation stages. Non-human primates recapitulate many aspects of human embryo development and provide crucial insights into trophoblast development, uterine receptivity and embryo invasion. Moreover, primate species exhibit a variety of implantation strategies and differ in embryo invasion depths. This review examines conservation and divergence of the key processes required for embryo implantation in different primates and in comparison with the canonical rodent model. We discuss trophectoderm compartmentalization, endometrial remodelling and embryo adhesion and invasion. Finally, we propose that studying the mechanism controlling invasion depth between different primate species may provide new insights and treatment strategies for placentation disorders in humans. This article is part of the theme issue ‘Extraembryonic tissues: exploring concepts, definitions and functions across the animal kingdom’. The Royal Society 2022-12-05 2022-10-17 /pmc/articles/PMC9574630/ /pubmed/36252209 http://dx.doi.org/10.1098/rstb.2021.0256 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Siriwardena, Dylan Boroviak, Thorsten E. Evolutionary divergence of embryo implantation in primates |
title | Evolutionary divergence of embryo implantation in primates |
title_full | Evolutionary divergence of embryo implantation in primates |
title_fullStr | Evolutionary divergence of embryo implantation in primates |
title_full_unstemmed | Evolutionary divergence of embryo implantation in primates |
title_short | Evolutionary divergence of embryo implantation in primates |
title_sort | evolutionary divergence of embryo implantation in primates |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574630/ https://www.ncbi.nlm.nih.gov/pubmed/36252209 http://dx.doi.org/10.1098/rstb.2021.0256 |
work_keys_str_mv | AT siriwardenadylan evolutionarydivergenceofembryoimplantationinprimates AT boroviakthorstene evolutionarydivergenceofembryoimplantationinprimates |