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A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification

Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have...

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Autores principales: QIAN, Yue-Tong, LIU, Jia-Wei, LIU, Wei, CHEN, Tian, TAN, Yan, MA, Dong-Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Publication of Acta Dermato-Venereologica 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574680/
https://www.ncbi.nlm.nih.gov/pubmed/35170741
http://dx.doi.org/10.2340/actadv.v102.1985
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author QIAN, Yue-Tong
LIU, Jia-Wei
LIU, Wei
CHEN, Tian
TAN, Yan
MA, Dong-Lai
author_facet QIAN, Yue-Tong
LIU, Jia-Wei
LIU, Wei
CHEN, Tian
TAN, Yan
MA, Dong-Lai
author_sort QIAN, Yue-Tong
collection PubMed
description Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have been reported. The aims of this retrospective study of 105 patients were to summarize the clinical and histological features of patients with this condition; to provide evidence for the viewpoint that elastolytic giant cell granuloma is a better term to include all clinical morphological types presenting with elastolysis, elastophagocytosis, and an infiltrate of multinucleated giant cells histologically; and to establish a new clinical classification. The varying clinical manifestations were further categorized into annular, papular, giant, mixed and generalized forms. The pathological manifestations were classified into giant cell, necrobiotic, histiocytic, sarcoidal and mixed patterns. Diabetes mellitus or impaired glucose tolerance were the most commonly identified comorbidities. Oral low-dose corticosteroid may be an effective treatment.
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spelling pubmed-95746802022-10-20 A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification QIAN, Yue-Tong LIU, Jia-Wei LIU, Wei CHEN, Tian TAN, Yan MA, Dong-Lai Acta Derm Venereol Original Article Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have been reported. The aims of this retrospective study of 105 patients were to summarize the clinical and histological features of patients with this condition; to provide evidence for the viewpoint that elastolytic giant cell granuloma is a better term to include all clinical morphological types presenting with elastolysis, elastophagocytosis, and an infiltrate of multinucleated giant cells histologically; and to establish a new clinical classification. The varying clinical manifestations were further categorized into annular, papular, giant, mixed and generalized forms. The pathological manifestations were classified into giant cell, necrobiotic, histiocytic, sarcoidal and mixed patterns. Diabetes mellitus or impaired glucose tolerance were the most commonly identified comorbidities. Oral low-dose corticosteroid may be an effective treatment. Society for Publication of Acta Dermato-Venereologica 2022-03-28 /pmc/articles/PMC9574680/ /pubmed/35170741 http://dx.doi.org/10.2340/actadv.v102.1985 Text en © 2022 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license
spellingShingle Original Article
QIAN, Yue-Tong
LIU, Jia-Wei
LIU, Wei
CHEN, Tian
TAN, Yan
MA, Dong-Lai
A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification
title A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification
title_full A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification
title_fullStr A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification
title_full_unstemmed A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification
title_short A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification
title_sort retrospective study of 105 patients with elastolytic giant cell granuloma and a proposal for a new clinical classification
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574680/
https://www.ncbi.nlm.nih.gov/pubmed/35170741
http://dx.doi.org/10.2340/actadv.v102.1985
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