Cargando…
A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification
Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Publication of Acta Dermato-Venereologica
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574680/ https://www.ncbi.nlm.nih.gov/pubmed/35170741 http://dx.doi.org/10.2340/actadv.v102.1985 |
_version_ | 1784811153505910784 |
---|---|
author | QIAN, Yue-Tong LIU, Jia-Wei LIU, Wei CHEN, Tian TAN, Yan MA, Dong-Lai |
author_facet | QIAN, Yue-Tong LIU, Jia-Wei LIU, Wei CHEN, Tian TAN, Yan MA, Dong-Lai |
author_sort | QIAN, Yue-Tong |
collection | PubMed |
description | Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have been reported. The aims of this retrospective study of 105 patients were to summarize the clinical and histological features of patients with this condition; to provide evidence for the viewpoint that elastolytic giant cell granuloma is a better term to include all clinical morphological types presenting with elastolysis, elastophagocytosis, and an infiltrate of multinucleated giant cells histologically; and to establish a new clinical classification. The varying clinical manifestations were further categorized into annular, papular, giant, mixed and generalized forms. The pathological manifestations were classified into giant cell, necrobiotic, histiocytic, sarcoidal and mixed patterns. Diabetes mellitus or impaired glucose tolerance were the most commonly identified comorbidities. Oral low-dose corticosteroid may be an effective treatment. |
format | Online Article Text |
id | pubmed-9574680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Society for Publication of Acta Dermato-Venereologica |
record_format | MEDLINE/PubMed |
spelling | pubmed-95746802022-10-20 A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification QIAN, Yue-Tong LIU, Jia-Wei LIU, Wei CHEN, Tian TAN, Yan MA, Dong-Lai Acta Derm Venereol Original Article Elastolytic giant cell granuloma, an idiopathic granulomatous dermatosis, is characterized by annular plaques on sun-exposed areas, and has been termed actinic granuloma or annular elastolytic giant cell granuloma. Many atypical clinical manifestations and lesions involving sun-protected areas have been reported. The aims of this retrospective study of 105 patients were to summarize the clinical and histological features of patients with this condition; to provide evidence for the viewpoint that elastolytic giant cell granuloma is a better term to include all clinical morphological types presenting with elastolysis, elastophagocytosis, and an infiltrate of multinucleated giant cells histologically; and to establish a new clinical classification. The varying clinical manifestations were further categorized into annular, papular, giant, mixed and generalized forms. The pathological manifestations were classified into giant cell, necrobiotic, histiocytic, sarcoidal and mixed patterns. Diabetes mellitus or impaired glucose tolerance were the most commonly identified comorbidities. Oral low-dose corticosteroid may be an effective treatment. Society for Publication of Acta Dermato-Venereologica 2022-03-28 /pmc/articles/PMC9574680/ /pubmed/35170741 http://dx.doi.org/10.2340/actadv.v102.1985 Text en © 2022 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the CC BY-NC license |
spellingShingle | Original Article QIAN, Yue-Tong LIU, Jia-Wei LIU, Wei CHEN, Tian TAN, Yan MA, Dong-Lai A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification |
title | A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification |
title_full | A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification |
title_fullStr | A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification |
title_full_unstemmed | A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification |
title_short | A Retrospective Study of 105 Patients with Elastolytic Giant Cell Granuloma and a Proposal for a New Clinical Classification |
title_sort | retrospective study of 105 patients with elastolytic giant cell granuloma and a proposal for a new clinical classification |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574680/ https://www.ncbi.nlm.nih.gov/pubmed/35170741 http://dx.doi.org/10.2340/actadv.v102.1985 |
work_keys_str_mv | AT qianyuetong aretrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT liujiawei aretrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT liuwei aretrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT chentian aretrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT tanyan aretrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT madonglai aretrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT qianyuetong retrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT liujiawei retrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT liuwei retrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT chentian retrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT tanyan retrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification AT madonglai retrospectivestudyof105patientswithelastolyticgiantcellgranulomaandaproposalforanewclinicalclassification |