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The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
BACKGROUND AND PURPOSE: White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients is relatively less researched. The primary aim of this study is to explore its prognosti...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574706/ https://www.ncbi.nlm.nih.gov/pubmed/36263052 http://dx.doi.org/10.3389/fimmu.2022.995911 |
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author | Weng, Yiyun Gao, Yufan Zhao, Mingyue Zeng, Tian Huang, Jiaqi Xie, Haobo Huang, Jiexi Chen, Yiqun Hu, Xiaoya Xu, Jiahan Zhu, Jinrong Lin, Suichai Ke, Tingting Li, Xiang Zhang, Xu |
author_facet | Weng, Yiyun Gao, Yufan Zhao, Mingyue Zeng, Tian Huang, Jiaqi Xie, Haobo Huang, Jiexi Chen, Yiqun Hu, Xiaoya Xu, Jiahan Zhu, Jinrong Lin, Suichai Ke, Tingting Li, Xiang Zhang, Xu |
author_sort | Weng, Yiyun |
collection | PubMed |
description | BACKGROUND AND PURPOSE: White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients is relatively less researched. The primary aim of this study is to explore its prognostic value in AIS patients after reperfusion regarding 3-month poor functional outcome. METHODS: A total of 549 AIS patients who had undergone vascular reperfusion procedure with complete 3-month follow-up were retrospectively recruited in this study. White blood cell count, mean platelet volume at 24 h of admission were recorded. Stroke severity had been estimated using the National Institutes of Health Stroke Scale (NIHSS) and poor outcome was defined as modified Rankin Scale (mRS) 3–6 at 3 months. RESULTS: AIS patients with poor functional outcome at 3 months displayed higher WMR. A positive correlation between WMR and NIHSS score was found (r = 0.334, p < 0.001). After adjusting potential confounders, WMR was still an independent risk factor for poor prognosis at 3 months (OR = 2.257, 95% CI [1.117-4.564], p = 0.023) in multivariate logistic regression model. Subgroup analyses further suggested a significant association between WMR and poor outcome in high baseline NIHSS (per 0.1-point increase: OR = 1.153, 95% CI [1.014-1.312], p = 0.030) group. Receiver operating characteristic (ROC) curves analysis was utilized to assess the predictive ability of WMR, indicating a cut-off value of 0.86. A nomogram that includes age, sex, NIHSS on admission, high WMR for predicting 1-year all-cause survival was also developed (C-index = 0.628). CONCLUSIONS: WMR is significantly correlated with stroke severity on admission and is proved to be an important prognostic indicator for AIS outcomes, especially in high NIHSS on admission group. Additionally, the developed nomogram that includes high WMR for predicting 1-year survival provides us with an effective visualization tool. |
format | Online Article Text |
id | pubmed-9574706 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95747062022-10-18 The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis Weng, Yiyun Gao, Yufan Zhao, Mingyue Zeng, Tian Huang, Jiaqi Xie, Haobo Huang, Jiexi Chen, Yiqun Hu, Xiaoya Xu, Jiahan Zhu, Jinrong Lin, Suichai Ke, Tingting Li, Xiang Zhang, Xu Front Immunol Immunology BACKGROUND AND PURPOSE: White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients is relatively less researched. The primary aim of this study is to explore its prognostic value in AIS patients after reperfusion regarding 3-month poor functional outcome. METHODS: A total of 549 AIS patients who had undergone vascular reperfusion procedure with complete 3-month follow-up were retrospectively recruited in this study. White blood cell count, mean platelet volume at 24 h of admission were recorded. Stroke severity had been estimated using the National Institutes of Health Stroke Scale (NIHSS) and poor outcome was defined as modified Rankin Scale (mRS) 3–6 at 3 months. RESULTS: AIS patients with poor functional outcome at 3 months displayed higher WMR. A positive correlation between WMR and NIHSS score was found (r = 0.334, p < 0.001). After adjusting potential confounders, WMR was still an independent risk factor for poor prognosis at 3 months (OR = 2.257, 95% CI [1.117-4.564], p = 0.023) in multivariate logistic regression model. Subgroup analyses further suggested a significant association between WMR and poor outcome in high baseline NIHSS (per 0.1-point increase: OR = 1.153, 95% CI [1.014-1.312], p = 0.030) group. Receiver operating characteristic (ROC) curves analysis was utilized to assess the predictive ability of WMR, indicating a cut-off value of 0.86. A nomogram that includes age, sex, NIHSS on admission, high WMR for predicting 1-year all-cause survival was also developed (C-index = 0.628). CONCLUSIONS: WMR is significantly correlated with stroke severity on admission and is proved to be an important prognostic indicator for AIS outcomes, especially in high NIHSS on admission group. Additionally, the developed nomogram that includes high WMR for predicting 1-year survival provides us with an effective visualization tool. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9574706/ /pubmed/36263052 http://dx.doi.org/10.3389/fimmu.2022.995911 Text en Copyright © 2022 Weng, Gao, Zhao, Zeng, Huang, Xie, Huang, Chen, Hu, Xu, Zhu, Lin, Ke, Li and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Weng, Yiyun Gao, Yufan Zhao, Mingyue Zeng, Tian Huang, Jiaqi Xie, Haobo Huang, Jiexi Chen, Yiqun Hu, Xiaoya Xu, Jiahan Zhu, Jinrong Lin, Suichai Ke, Tingting Li, Xiang Zhang, Xu The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis |
title | The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis |
title_full | The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis |
title_fullStr | The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis |
title_full_unstemmed | The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis |
title_short | The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis |
title_sort | white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574706/ https://www.ncbi.nlm.nih.gov/pubmed/36263052 http://dx.doi.org/10.3389/fimmu.2022.995911 |
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