Cargando…

The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis

BACKGROUND AND PURPOSE: White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients is relatively less researched. The primary aim of this study is to explore its prognosti...

Descripción completa

Detalles Bibliográficos
Autores principales: Weng, Yiyun, Gao, Yufan, Zhao, Mingyue, Zeng, Tian, Huang, Jiaqi, Xie, Haobo, Huang, Jiexi, Chen, Yiqun, Hu, Xiaoya, Xu, Jiahan, Zhu, Jinrong, Lin, Suichai, Ke, Tingting, Li, Xiang, Zhang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574706/
https://www.ncbi.nlm.nih.gov/pubmed/36263052
http://dx.doi.org/10.3389/fimmu.2022.995911
_version_ 1784811159927390208
author Weng, Yiyun
Gao, Yufan
Zhao, Mingyue
Zeng, Tian
Huang, Jiaqi
Xie, Haobo
Huang, Jiexi
Chen, Yiqun
Hu, Xiaoya
Xu, Jiahan
Zhu, Jinrong
Lin, Suichai
Ke, Tingting
Li, Xiang
Zhang, Xu
author_facet Weng, Yiyun
Gao, Yufan
Zhao, Mingyue
Zeng, Tian
Huang, Jiaqi
Xie, Haobo
Huang, Jiexi
Chen, Yiqun
Hu, Xiaoya
Xu, Jiahan
Zhu, Jinrong
Lin, Suichai
Ke, Tingting
Li, Xiang
Zhang, Xu
author_sort Weng, Yiyun
collection PubMed
description BACKGROUND AND PURPOSE: White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients is relatively less researched. The primary aim of this study is to explore its prognostic value in AIS patients after reperfusion regarding 3-month poor functional outcome. METHODS: A total of 549 AIS patients who had undergone vascular reperfusion procedure with complete 3-month follow-up were retrospectively recruited in this study. White blood cell count, mean platelet volume at 24 h of admission were recorded. Stroke severity had been estimated using the National Institutes of Health Stroke Scale (NIHSS) and poor outcome was defined as modified Rankin Scale (mRS) 3–6 at 3 months. RESULTS: AIS patients with poor functional outcome at 3 months displayed higher WMR. A positive correlation between WMR and NIHSS score was found (r = 0.334, p < 0.001). After adjusting potential confounders, WMR was still an independent risk factor for poor prognosis at 3 months (OR = 2.257, 95% CI [1.117-4.564], p = 0.023) in multivariate logistic regression model. Subgroup analyses further suggested a significant association between WMR and poor outcome in high baseline NIHSS (per 0.1-point increase: OR = 1.153, 95% CI [1.014-1.312], p = 0.030) group. Receiver operating characteristic (ROC) curves analysis was utilized to assess the predictive ability of WMR, indicating a cut-off value of 0.86. A nomogram that includes age, sex, NIHSS on admission, high WMR for predicting 1-year all-cause survival was also developed (C-index = 0.628). CONCLUSIONS: WMR is significantly correlated with stroke severity on admission and is proved to be an important prognostic indicator for AIS outcomes, especially in high NIHSS on admission group. Additionally, the developed nomogram that includes high WMR for predicting 1-year survival provides us with an effective visualization tool.
format Online
Article
Text
id pubmed-9574706
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95747062022-10-18 The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis Weng, Yiyun Gao, Yufan Zhao, Mingyue Zeng, Tian Huang, Jiaqi Xie, Haobo Huang, Jiexi Chen, Yiqun Hu, Xiaoya Xu, Jiahan Zhu, Jinrong Lin, Suichai Ke, Tingting Li, Xiang Zhang, Xu Front Immunol Immunology BACKGROUND AND PURPOSE: White blood cell count to mean platelet volume ratio (WMR) is increasingly recognized as a promising biomarker. However, its predictive capability for acute ischemic stroke (AIS) patients is relatively less researched. The primary aim of this study is to explore its prognostic value in AIS patients after reperfusion regarding 3-month poor functional outcome. METHODS: A total of 549 AIS patients who had undergone vascular reperfusion procedure with complete 3-month follow-up were retrospectively recruited in this study. White blood cell count, mean platelet volume at 24 h of admission were recorded. Stroke severity had been estimated using the National Institutes of Health Stroke Scale (NIHSS) and poor outcome was defined as modified Rankin Scale (mRS) 3–6 at 3 months. RESULTS: AIS patients with poor functional outcome at 3 months displayed higher WMR. A positive correlation between WMR and NIHSS score was found (r = 0.334, p < 0.001). After adjusting potential confounders, WMR was still an independent risk factor for poor prognosis at 3 months (OR = 2.257, 95% CI [1.117-4.564], p = 0.023) in multivariate logistic regression model. Subgroup analyses further suggested a significant association between WMR and poor outcome in high baseline NIHSS (per 0.1-point increase: OR = 1.153, 95% CI [1.014-1.312], p = 0.030) group. Receiver operating characteristic (ROC) curves analysis was utilized to assess the predictive ability of WMR, indicating a cut-off value of 0.86. A nomogram that includes age, sex, NIHSS on admission, high WMR for predicting 1-year all-cause survival was also developed (C-index = 0.628). CONCLUSIONS: WMR is significantly correlated with stroke severity on admission and is proved to be an important prognostic indicator for AIS outcomes, especially in high NIHSS on admission group. Additionally, the developed nomogram that includes high WMR for predicting 1-year survival provides us with an effective visualization tool. Frontiers Media S.A. 2022-10-03 /pmc/articles/PMC9574706/ /pubmed/36263052 http://dx.doi.org/10.3389/fimmu.2022.995911 Text en Copyright © 2022 Weng, Gao, Zhao, Zeng, Huang, Xie, Huang, Chen, Hu, Xu, Zhu, Lin, Ke, Li and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Weng, Yiyun
Gao, Yufan
Zhao, Mingyue
Zeng, Tian
Huang, Jiaqi
Xie, Haobo
Huang, Jiexi
Chen, Yiqun
Hu, Xiaoya
Xu, Jiahan
Zhu, Jinrong
Lin, Suichai
Ke, Tingting
Li, Xiang
Zhang, Xu
The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
title The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
title_full The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
title_fullStr The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
title_full_unstemmed The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
title_short The white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
title_sort white blood cell count to mean platelet volume ratio for ischemic stroke patients after intravenous thrombolysis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574706/
https://www.ncbi.nlm.nih.gov/pubmed/36263052
http://dx.doi.org/10.3389/fimmu.2022.995911
work_keys_str_mv AT wengyiyun thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT gaoyufan thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zhaomingyue thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zengtian thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT huangjiaqi thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT xiehaobo thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT huangjiexi thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT chenyiqun thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT huxiaoya thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT xujiahan thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zhujinrong thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT linsuichai thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT ketingting thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT lixiang thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zhangxu thewhitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT wengyiyun whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT gaoyufan whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zhaomingyue whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zengtian whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT huangjiaqi whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT xiehaobo whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT huangjiexi whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT chenyiqun whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT huxiaoya whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT xujiahan whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zhujinrong whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT linsuichai whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT ketingting whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT lixiang whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis
AT zhangxu whitebloodcellcounttomeanplateletvolumeratioforischemicstrokepatientsafterintravenousthrombolysis