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Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package

The current tutorial describes why forest plots are needed for an effective communication of covariates effects, how they are constructed, and how they should be presented. Simulation‐based methodologies allowing the user to evaluate the marginal impact of changing one covariate at a time or by cons...

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Autores principales: Marier, Jean‐Francois, Teuscher, Nathan, Mouksassi, Mohamad‐Samer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574733/
https://www.ncbi.nlm.nih.gov/pubmed/35670230
http://dx.doi.org/10.1002/psp4.12829
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author Marier, Jean‐Francois
Teuscher, Nathan
Mouksassi, Mohamad‐Samer
author_facet Marier, Jean‐Francois
Teuscher, Nathan
Mouksassi, Mohamad‐Samer
author_sort Marier, Jean‐Francois
collection PubMed
description The current tutorial describes why forest plots are needed for an effective communication of covariates effects, how they are constructed, and how they should be presented. Simulation‐based methodologies allowing the user to evaluate the marginal impact of changing one covariate at a time or by considering the joint effects of correlated covariates are introduced along with graphical tools for an optimal assessment of the covariate effects. The R package coveffectsplot and an associated R Shiny application are provided to facilitate the design and construction of forest plots for the visualization of covariate effects. All codes and materials are available on a public Github repository.
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spelling pubmed-95747332022-10-17 Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package Marier, Jean‐Francois Teuscher, Nathan Mouksassi, Mohamad‐Samer CPT Pharmacometrics Syst Pharmacol Tutorial The current tutorial describes why forest plots are needed for an effective communication of covariates effects, how they are constructed, and how they should be presented. Simulation‐based methodologies allowing the user to evaluate the marginal impact of changing one covariate at a time or by considering the joint effects of correlated covariates are introduced along with graphical tools for an optimal assessment of the covariate effects. The R package coveffectsplot and an associated R Shiny application are provided to facilitate the design and construction of forest plots for the visualization of covariate effects. All codes and materials are available on a public Github repository. John Wiley and Sons Inc. 2022-06-27 2022-10 /pmc/articles/PMC9574733/ /pubmed/35670230 http://dx.doi.org/10.1002/psp4.12829 Text en © 2022 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Tutorial
Marier, Jean‐Francois
Teuscher, Nathan
Mouksassi, Mohamad‐Samer
Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package
title Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package
title_full Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package
title_fullStr Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package
title_full_unstemmed Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package
title_short Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package
title_sort evaluation of covariate effects using forest plots and introduction to the coveffectsplot r package
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574733/
https://www.ncbi.nlm.nih.gov/pubmed/35670230
http://dx.doi.org/10.1002/psp4.12829
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