Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis

INTRODUCTION: The present study aimed to investigate the antifungal activity of silver nanoparticles (SNPs) against agents of suspected rhino orbital mucormycosis. METHODS: Thirty-two strains were isolated from endoscopy-guided nasal swab and/or tissue biopsy after debridement/surgery on Sabouraud d...

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Autores principales: Chatterjee, Kuhu, Taneja, Juhi, Khullar, Shilpa, Pandey, Anil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574810/
https://www.ncbi.nlm.nih.gov/pubmed/36251128
http://dx.doi.org/10.1007/s10123-022-00280-7
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author Chatterjee, Kuhu
Taneja, Juhi
Khullar, Shilpa
Pandey, Anil Kumar
author_facet Chatterjee, Kuhu
Taneja, Juhi
Khullar, Shilpa
Pandey, Anil Kumar
author_sort Chatterjee, Kuhu
collection PubMed
description INTRODUCTION: The present study aimed to investigate the antifungal activity of silver nanoparticles (SNPs) against agents of suspected rhino orbital mucormycosis. METHODS: Thirty-two strains were isolated from endoscopy-guided nasal swab and/or tissue biopsy after debridement/surgery on Sabouraud dextrose agar without cyclohexamide. Antifungal activity was conducted according to Clinical and Laboratory Standards Institute’s (CLSI) guidelines, M38-A2. The average size of silver nanoparticle was less than 10 nm. RESULTS: Minimum inhibitory concentration (MIC) of nanoparticles of all strains was in the concentration range of 1–64 μg/ml and minimal fungicidal concentration (MFC) at 16–512 μg/ml. CONCLUSION: The SNPs revealed significant antifungal activity against agents of invasive mycosis.
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spelling pubmed-95748102022-10-17 Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis Chatterjee, Kuhu Taneja, Juhi Khullar, Shilpa Pandey, Anil Kumar Int Microbiol Original Article INTRODUCTION: The present study aimed to investigate the antifungal activity of silver nanoparticles (SNPs) against agents of suspected rhino orbital mucormycosis. METHODS: Thirty-two strains were isolated from endoscopy-guided nasal swab and/or tissue biopsy after debridement/surgery on Sabouraud dextrose agar without cyclohexamide. Antifungal activity was conducted according to Clinical and Laboratory Standards Institute’s (CLSI) guidelines, M38-A2. The average size of silver nanoparticle was less than 10 nm. RESULTS: Minimum inhibitory concentration (MIC) of nanoparticles of all strains was in the concentration range of 1–64 μg/ml and minimal fungicidal concentration (MFC) at 16–512 μg/ml. CONCLUSION: The SNPs revealed significant antifungal activity against agents of invasive mycosis. Springer International Publishing 2022-10-17 2023 /pmc/articles/PMC9574810/ /pubmed/36251128 http://dx.doi.org/10.1007/s10123-022-00280-7 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022, corrected publication 2022Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Chatterjee, Kuhu
Taneja, Juhi
Khullar, Shilpa
Pandey, Anil Kumar
Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis
title Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis
title_full Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis
title_fullStr Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis
title_full_unstemmed Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis
title_short Antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis
title_sort antifungal activity of silver nanoparticles on fungal isolates from patients of suspected mucormycosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574810/
https://www.ncbi.nlm.nih.gov/pubmed/36251128
http://dx.doi.org/10.1007/s10123-022-00280-7
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