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Can erythema multiforme be an immune sequela of IgM nephropathy? A case report

A 13-year-old Chinese girl attended to our Pediatric Dermatology Unit for the appearance of itchy targetoid lesions on the trunk, face and upper limbs. A skin biopsy showed histological findings typical of erythema multiforme minor. A month earlier she was admitted for the onset of a nephrotic syndr...

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Autores principales: Messina, Francesco, Fagotto, Laura, Caroppo, Francesca, Salmaso, Roberto, Belloni Fortina, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574842/
https://www.ncbi.nlm.nih.gov/pubmed/36253793
http://dx.doi.org/10.1186/s13052-022-01373-9
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author Messina, Francesco
Fagotto, Laura
Caroppo, Francesca
Salmaso, Roberto
Belloni Fortina, Anna
author_facet Messina, Francesco
Fagotto, Laura
Caroppo, Francesca
Salmaso, Roberto
Belloni Fortina, Anna
author_sort Messina, Francesco
collection PubMed
description A 13-year-old Chinese girl attended to our Pediatric Dermatology Unit for the appearance of itchy targetoid lesions on the trunk, face and upper limbs. A skin biopsy showed histological findings typical of erythema multiforme minor. A month earlier she was admitted for the onset of a nephrotic syndrome and the renal biopsy showed an IgM nephropathy with a diffuse mesangial cell proliferation. There was no medical history of recent infections, fever, muscle or joint pain, drugs intake related to erythema multiforme and viral serology were negative. The role of antibodies in erythema multiforme could be more relevant than suspected and the severity of erythema multiforme was reported to be proportional to the antibody-mediated complement-dependent cytotoxicity, supporting the potential pathogenetic role for humoral immunity in this subtype of erythema multiforme. We reported the first association of erythema multiforme and IgM nephropathy in a pediatric patient providing an additional hint that an antibody-mediated process, rather than T-cell cytotoxicity, might represent the main pathogenetic mechanism in certain subtypes of erythema multiforme.
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spelling pubmed-95748422022-10-17 Can erythema multiforme be an immune sequela of IgM nephropathy? A case report Messina, Francesco Fagotto, Laura Caroppo, Francesca Salmaso, Roberto Belloni Fortina, Anna Ital J Pediatr Letter to the Editor A 13-year-old Chinese girl attended to our Pediatric Dermatology Unit for the appearance of itchy targetoid lesions on the trunk, face and upper limbs. A skin biopsy showed histological findings typical of erythema multiforme minor. A month earlier she was admitted for the onset of a nephrotic syndrome and the renal biopsy showed an IgM nephropathy with a diffuse mesangial cell proliferation. There was no medical history of recent infections, fever, muscle or joint pain, drugs intake related to erythema multiforme and viral serology were negative. The role of antibodies in erythema multiforme could be more relevant than suspected and the severity of erythema multiforme was reported to be proportional to the antibody-mediated complement-dependent cytotoxicity, supporting the potential pathogenetic role for humoral immunity in this subtype of erythema multiforme. We reported the first association of erythema multiforme and IgM nephropathy in a pediatric patient providing an additional hint that an antibody-mediated process, rather than T-cell cytotoxicity, might represent the main pathogenetic mechanism in certain subtypes of erythema multiforme. BioMed Central 2022-10-17 /pmc/articles/PMC9574842/ /pubmed/36253793 http://dx.doi.org/10.1186/s13052-022-01373-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Messina, Francesco
Fagotto, Laura
Caroppo, Francesca
Salmaso, Roberto
Belloni Fortina, Anna
Can erythema multiforme be an immune sequela of IgM nephropathy? A case report
title Can erythema multiforme be an immune sequela of IgM nephropathy? A case report
title_full Can erythema multiforme be an immune sequela of IgM nephropathy? A case report
title_fullStr Can erythema multiforme be an immune sequela of IgM nephropathy? A case report
title_full_unstemmed Can erythema multiforme be an immune sequela of IgM nephropathy? A case report
title_short Can erythema multiforme be an immune sequela of IgM nephropathy? A case report
title_sort can erythema multiforme be an immune sequela of igm nephropathy? a case report
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574842/
https://www.ncbi.nlm.nih.gov/pubmed/36253793
http://dx.doi.org/10.1186/s13052-022-01373-9
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