Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

[Image: see text] In recent years, human dihydroorotate dehydrogenase inhibitors have been associated with acute myelogenous leukemia as well as studied as potent host targeting antivirals. Starting from MEDS433 (IC(50) 1.2 nM), we kept improving the structure–activity relationship of this class of...

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Autores principales: Sainas, Stefano, Giorgis, Marta, Circosta, Paola, Poli, Giulio, Alberti, Marta, Passoni, Alice, Gaidano, Valentina, Pippione, Agnese C., Vitale, Nicoletta, Bonanni, Davide, Rolando, Barbara, Cignetti, Alessandro, Ramondetti, Cristina, Lanno, Alessia, Ferraris, Davide M., Canepa, Barbara, Buccinnà, Barbara, Piccinini, Marco, Rizzi, Menico, Saglio, Giuseppe, Al-Karadaghi, Salam, Boschi, Donatella, Miggiano, Riccardo, Tuccinardi, Tiziano, Lolli, Marco L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574863/
https://www.ncbi.nlm.nih.gov/pubmed/36162075
http://dx.doi.org/10.1021/acs.jmedchem.2c00496

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