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Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis

[Image: see text] An effective therapeutic approach based on the anti-inflammatory action of hydrogen sulfide (H(2)S) and inhibition of carbonic anhydrases (CAs) IX and XII is proposed here for the management of arthritis. H(2)S is a human gasotransmitter that modulates inflammatory response at low...

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Detalles Bibliográficos
Autores principales:	Bonardi, Alessandro, Micheli, Laura, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Gratteri, Paola, Nocentini, Alessio, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574929/ https://www.ncbi.nlm.nih.gov/pubmed/36121705 http://dx.doi.org/10.1021/acs.jmedchem.2c00982

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