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Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss

OBJECTIVES/HYPOTHESIS: The objective of this study is to describe long‐term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV. STUDY TYPE: Clinical research study. DESIGN: Retrospective cohort study. METHODS: Retrospectiv...

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Autores principales: Raynor, Eileen M., Martin, Hannah L., Poehlein, Emily, Lee, Hui‐Jie, Lantos, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575047/
https://www.ncbi.nlm.nih.gov/pubmed/36258861
http://dx.doi.org/10.1002/lio2.904
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author Raynor, Eileen M.
Martin, Hannah L.
Poehlein, Emily
Lee, Hui‐Jie
Lantos, Paul
author_facet Raynor, Eileen M.
Martin, Hannah L.
Poehlein, Emily
Lee, Hui‐Jie
Lantos, Paul
author_sort Raynor, Eileen M.
collection PubMed
description OBJECTIVES/HYPOTHESIS: The objective of this study is to describe long‐term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV. STUDY TYPE: Clinical research study. DESIGN: Retrospective cohort study. METHODS: Retrospective chart review was performed for mothers seropositive to CMV. Mother–infant dyads (130) were identified between January 1, 2013 and January 1, 2017. Outcomes data was collected through June 1, 2020. Demographics, risk factors for hearing loss, evidence of CMV infection, other causes of hearing loss, need for speech therapy services, and results of all hearing tests were collected. RESULTS: All 130 infants were asymptomatic and 5 were tested for congenital CMV. Five were negative for CMV and excluded from analyses. Of the remaining 125, only 1 had low‐viral avidity IgG antibodies. None had IgM antibodies. Four children (3.2%) had hearing loss at last audiogram and one child had delayed onset SNHL due to an enlarged vestibular aqueduct. Speech therapy for communication was required for 33 children (26.4%). CONCLUSIONS: Knowledge of maternal perinatal CMV status can allow for education about possible sequelae of cCMV, as well as trigger an alert for testing babies born to mothers with low‐viral avidity IgG during the first trimester, when the risk of vertical transmission is highest. Also, babies born to CMV positive mothers may be more at risk for communication delays necessitating intervention. Studies focusing on the impact of maternal CMV related to childhood communication deficits could elucidate any direct relationships.
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spelling pubmed-95750472022-10-17 Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss Raynor, Eileen M. Martin, Hannah L. Poehlein, Emily Lee, Hui‐Jie Lantos, Paul Laryngoscope Investig Otolaryngol Pediatrics and Development OBJECTIVES/HYPOTHESIS: The objective of this study is to describe long‐term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV. STUDY TYPE: Clinical research study. DESIGN: Retrospective cohort study. METHODS: Retrospective chart review was performed for mothers seropositive to CMV. Mother–infant dyads (130) were identified between January 1, 2013 and January 1, 2017. Outcomes data was collected through June 1, 2020. Demographics, risk factors for hearing loss, evidence of CMV infection, other causes of hearing loss, need for speech therapy services, and results of all hearing tests were collected. RESULTS: All 130 infants were asymptomatic and 5 were tested for congenital CMV. Five were negative for CMV and excluded from analyses. Of the remaining 125, only 1 had low‐viral avidity IgG antibodies. None had IgM antibodies. Four children (3.2%) had hearing loss at last audiogram and one child had delayed onset SNHL due to an enlarged vestibular aqueduct. Speech therapy for communication was required for 33 children (26.4%). CONCLUSIONS: Knowledge of maternal perinatal CMV status can allow for education about possible sequelae of cCMV, as well as trigger an alert for testing babies born to mothers with low‐viral avidity IgG during the first trimester, when the risk of vertical transmission is highest. Also, babies born to CMV positive mothers may be more at risk for communication delays necessitating intervention. Studies focusing on the impact of maternal CMV related to childhood communication deficits could elucidate any direct relationships. John Wiley & Sons, Inc. 2022-08-29 /pmc/articles/PMC9575047/ /pubmed/36258861 http://dx.doi.org/10.1002/lio2.904 Text en © 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Pediatrics and Development
Raynor, Eileen M.
Martin, Hannah L.
Poehlein, Emily
Lee, Hui‐Jie
Lantos, Paul
Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
title Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
title_full Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
title_fullStr Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
title_full_unstemmed Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
title_short Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
title_sort impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
topic Pediatrics and Development
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575047/
https://www.ncbi.nlm.nih.gov/pubmed/36258861
http://dx.doi.org/10.1002/lio2.904
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