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Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss
OBJECTIVES/HYPOTHESIS: The objective of this study is to describe long‐term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV. STUDY TYPE: Clinical research study. DESIGN: Retrospective cohort study. METHODS: Retrospectiv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575047/ https://www.ncbi.nlm.nih.gov/pubmed/36258861 http://dx.doi.org/10.1002/lio2.904 |
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author | Raynor, Eileen M. Martin, Hannah L. Poehlein, Emily Lee, Hui‐Jie Lantos, Paul |
author_facet | Raynor, Eileen M. Martin, Hannah L. Poehlein, Emily Lee, Hui‐Jie Lantos, Paul |
author_sort | Raynor, Eileen M. |
collection | PubMed |
description | OBJECTIVES/HYPOTHESIS: The objective of this study is to describe long‐term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV. STUDY TYPE: Clinical research study. DESIGN: Retrospective cohort study. METHODS: Retrospective chart review was performed for mothers seropositive to CMV. Mother–infant dyads (130) were identified between January 1, 2013 and January 1, 2017. Outcomes data was collected through June 1, 2020. Demographics, risk factors for hearing loss, evidence of CMV infection, other causes of hearing loss, need for speech therapy services, and results of all hearing tests were collected. RESULTS: All 130 infants were asymptomatic and 5 were tested for congenital CMV. Five were negative for CMV and excluded from analyses. Of the remaining 125, only 1 had low‐viral avidity IgG antibodies. None had IgM antibodies. Four children (3.2%) had hearing loss at last audiogram and one child had delayed onset SNHL due to an enlarged vestibular aqueduct. Speech therapy for communication was required for 33 children (26.4%). CONCLUSIONS: Knowledge of maternal perinatal CMV status can allow for education about possible sequelae of cCMV, as well as trigger an alert for testing babies born to mothers with low‐viral avidity IgG during the first trimester, when the risk of vertical transmission is highest. Also, babies born to CMV positive mothers may be more at risk for communication delays necessitating intervention. Studies focusing on the impact of maternal CMV related to childhood communication deficits could elucidate any direct relationships. |
format | Online Article Text |
id | pubmed-9575047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95750472022-10-17 Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss Raynor, Eileen M. Martin, Hannah L. Poehlein, Emily Lee, Hui‐Jie Lantos, Paul Laryngoscope Investig Otolaryngol Pediatrics and Development OBJECTIVES/HYPOTHESIS: The objective of this study is to describe long‐term hearing outcomes in infants born to mothers with a known cytomegalovirus (CMV) positivity who were not tested for congenital CMV. STUDY TYPE: Clinical research study. DESIGN: Retrospective cohort study. METHODS: Retrospective chart review was performed for mothers seropositive to CMV. Mother–infant dyads (130) were identified between January 1, 2013 and January 1, 2017. Outcomes data was collected through June 1, 2020. Demographics, risk factors for hearing loss, evidence of CMV infection, other causes of hearing loss, need for speech therapy services, and results of all hearing tests were collected. RESULTS: All 130 infants were asymptomatic and 5 were tested for congenital CMV. Five were negative for CMV and excluded from analyses. Of the remaining 125, only 1 had low‐viral avidity IgG antibodies. None had IgM antibodies. Four children (3.2%) had hearing loss at last audiogram and one child had delayed onset SNHL due to an enlarged vestibular aqueduct. Speech therapy for communication was required for 33 children (26.4%). CONCLUSIONS: Knowledge of maternal perinatal CMV status can allow for education about possible sequelae of cCMV, as well as trigger an alert for testing babies born to mothers with low‐viral avidity IgG during the first trimester, when the risk of vertical transmission is highest. Also, babies born to CMV positive mothers may be more at risk for communication delays necessitating intervention. Studies focusing on the impact of maternal CMV related to childhood communication deficits could elucidate any direct relationships. John Wiley & Sons, Inc. 2022-08-29 /pmc/articles/PMC9575047/ /pubmed/36258861 http://dx.doi.org/10.1002/lio2.904 Text en © 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Pediatrics and Development Raynor, Eileen M. Martin, Hannah L. Poehlein, Emily Lee, Hui‐Jie Lantos, Paul Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss |
title | Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss |
title_full | Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss |
title_fullStr | Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss |
title_full_unstemmed | Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss |
title_short | Impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss |
title_sort | impact of maternal cytomegalovirus seroconversion on newborn and childhood hearing loss |
topic | Pediatrics and Development |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575047/ https://www.ncbi.nlm.nih.gov/pubmed/36258861 http://dx.doi.org/10.1002/lio2.904 |
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