Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss

BACKGROUND: Salvage intratympanic steroids (ITS) works in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) after failure of initial therapy, but optimal timing of administration is unknown. METHODS: Two hundred and seventy patients with ISSNHL were included. Among them, 180 were t...

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Autores principales: Wu, Yongzhen, Song, Zijun, Wang, Yi, Zhao, Hui, Ren, Tongli, Jing, Jianghua, Gao, Na, Qiao, Liang, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Otology, Neurotology, and Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575068/
https://www.ncbi.nlm.nih.gov/pubmed/36258873
http://dx.doi.org/10.1002/lio2.909
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author Wu, Yongzhen
Song, Zijun
Wang, Yi
Zhao, Hui
Ren, Tongli
Jing, Jianghua
Gao, Na
Qiao, Liang
Wang, Jing
author_facet Wu, Yongzhen
Song, Zijun
Wang, Yi
Zhao, Hui
Ren, Tongli
Jing, Jianghua
Gao, Na
Qiao, Liang
Wang, Jing
author_sort Wu, Yongzhen
collection PubMed
description BACKGROUND: Salvage intratympanic steroids (ITS) works in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) after failure of initial therapy, but optimal timing of administration is unknown. METHODS: Two hundred and seventy patients with ISSNHL were included. Among them, 180 were treated with ITS and standard medical treatment (SMT) and the other 90 received SMT along. The hearing threshold before and after salvage treatment were compared. The relationship between the salvage starting time and hearing recovery was analyzed. RESULTS: The hearing of ITS group improved more than that of the SMT group in all frequency bands. The effect of both strategies decreases with the delay of the starting time. ITS can improve hearing even if being administrated 5 weeks after onset while SMT failed after 3 weeks. CONCLUSION: Patients with profound ISSNHL can obtain extra hearing recovery from salvage ITS. The earlier salvage starts, the greater the patient benefits.
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spelling pubmed-95750682022-10-17 Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss Wu, Yongzhen Song, Zijun Wang, Yi Zhao, Hui Ren, Tongli Jing, Jianghua Gao, Na Qiao, Liang Wang, Jing Laryngoscope Investig Otolaryngol Otology, Neurotology, and Neuroscience BACKGROUND: Salvage intratympanic steroids (ITS) works in patients with idiopathic sudden sensorineural hearing loss (ISSNHL) after failure of initial therapy, but optimal timing of administration is unknown. METHODS: Two hundred and seventy patients with ISSNHL were included. Among them, 180 were treated with ITS and standard medical treatment (SMT) and the other 90 received SMT along. The hearing threshold before and after salvage treatment were compared. The relationship between the salvage starting time and hearing recovery was analyzed. RESULTS: The hearing of ITS group improved more than that of the SMT group in all frequency bands. The effect of both strategies decreases with the delay of the starting time. ITS can improve hearing even if being administrated 5 weeks after onset while SMT failed after 3 weeks. CONCLUSION: Patients with profound ISSNHL can obtain extra hearing recovery from salvage ITS. The earlier salvage starts, the greater the patient benefits. John Wiley & Sons, Inc. 2022-09-14 /pmc/articles/PMC9575068/ /pubmed/36258873 http://dx.doi.org/10.1002/lio2.909 Text en © 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC. on behalf of The Triological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Otology, Neurotology, and Neuroscience
Wu, Yongzhen
Song, Zijun
Wang, Yi
Zhao, Hui
Ren, Tongli
Jing, Jianghua
Gao, Na
Qiao, Liang
Wang, Jing
Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
title Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
title_full Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
title_fullStr Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
title_full_unstemmed Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
title_short Optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
title_sort optimal timing of salvage intratympanic steroids in idiopathic sudden sensorineural hearing loss
topic Otology, Neurotology, and Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575068/
https://www.ncbi.nlm.nih.gov/pubmed/36258873
http://dx.doi.org/10.1002/lio2.909
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