Cargando…

Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study

OBJECTIVES: The development of sialolithiasis is commonly related to local factors, such as the retrograde migration of foods, bacteria, or foreign bodies from the oral cavity. The association of sialolithiasis and saliva stasis resulting from decreased spontaneous secretion remains largely unexplor...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yen‐Chun, Dang, Luong Huu, Chang, Wei‐Wen, Su, Chin‐Hui, Hung, Shih‐Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575085/
https://www.ncbi.nlm.nih.gov/pubmed/36258884
http://dx.doi.org/10.1002/lio2.882
_version_ 1784811246621556736
author Chen, Yen‐Chun
Dang, Luong Huu
Chang, Wei‐Wen
Su, Chin‐Hui
Hung, Shih‐Han
author_facet Chen, Yen‐Chun
Dang, Luong Huu
Chang, Wei‐Wen
Su, Chin‐Hui
Hung, Shih‐Han
author_sort Chen, Yen‐Chun
collection PubMed
description OBJECTIVES: The development of sialolithiasis is commonly related to local factors, such as the retrograde migration of foods, bacteria, or foreign bodies from the oral cavity. The association of sialolithiasis and saliva stasis resulting from decreased spontaneous secretion remains largely unexplored. The current study investigated the potential role of impaired spontaneous secretion in association with the formation of submandibular gland calculi. STUDY DESIGN: A retrospective cohort study. METHODS: Between September 2016 and December 2017, 11 patients with unilateral submandibular gland sialolithiasis confirmed with sialendoscopy were assigned to the experimental group. Another 35 patients clinically diagnosed with parotid obstructive sialadenitis were assigned as the control group. The slope changes of the isotope count curve of the unaffected submandibular gland in the experimental group and the bilateral submandibular glands in the control group were calculated and compared to estimate the spontaneous secretion differences. The degree of spontaneous secretion was defined as the slope changes in the steady ascending stage of the scintigraphic exam. RESULTS: The slope decline (degree of spontaneous secretion) on the unaffected side in patients with single‐gland submandibular obstructive sialadenitis was significantly lower than that in the control individuals (p = .002). In contrast, the between‐group comparison in the unaffected parotid glands revealed no difference in the slope decline. CONCLUSION: The spontaneous secretion of the submandibular gland in patients with submandibular sialolithiasis was decreased compared to that in patients without submandibular sialolithiasis. This phenomenon might be associated with the development of sialolithiasis. LEVEL OF EVIDENCE: 3.
format Online
Article
Text
id pubmed-9575085
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-95750852022-10-17 Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study Chen, Yen‐Chun Dang, Luong Huu Chang, Wei‐Wen Su, Chin‐Hui Hung, Shih‐Han Laryngoscope Investig Otolaryngol Comprehensive (General) Otolaryngology OBJECTIVES: The development of sialolithiasis is commonly related to local factors, such as the retrograde migration of foods, bacteria, or foreign bodies from the oral cavity. The association of sialolithiasis and saliva stasis resulting from decreased spontaneous secretion remains largely unexplored. The current study investigated the potential role of impaired spontaneous secretion in association with the formation of submandibular gland calculi. STUDY DESIGN: A retrospective cohort study. METHODS: Between September 2016 and December 2017, 11 patients with unilateral submandibular gland sialolithiasis confirmed with sialendoscopy were assigned to the experimental group. Another 35 patients clinically diagnosed with parotid obstructive sialadenitis were assigned as the control group. The slope changes of the isotope count curve of the unaffected submandibular gland in the experimental group and the bilateral submandibular glands in the control group were calculated and compared to estimate the spontaneous secretion differences. The degree of spontaneous secretion was defined as the slope changes in the steady ascending stage of the scintigraphic exam. RESULTS: The slope decline (degree of spontaneous secretion) on the unaffected side in patients with single‐gland submandibular obstructive sialadenitis was significantly lower than that in the control individuals (p = .002). In contrast, the between‐group comparison in the unaffected parotid glands revealed no difference in the slope decline. CONCLUSION: The spontaneous secretion of the submandibular gland in patients with submandibular sialolithiasis was decreased compared to that in patients without submandibular sialolithiasis. This phenomenon might be associated with the development of sialolithiasis. LEVEL OF EVIDENCE: 3. John Wiley & Sons, Inc. 2022-08-02 /pmc/articles/PMC9575085/ /pubmed/36258884 http://dx.doi.org/10.1002/lio2.882 Text en © 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Comprehensive (General) Otolaryngology
Chen, Yen‐Chun
Dang, Luong Huu
Chang, Wei‐Wen
Su, Chin‐Hui
Hung, Shih‐Han
Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study
title Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study
title_full Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study
title_fullStr Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study
title_full_unstemmed Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study
title_short Impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: A preliminary sialoscintigraphic study
title_sort impaired spontaneous secretion as a potential factor in the development of sialolithiasis in the submandibular gland: a preliminary sialoscintigraphic study
topic Comprehensive (General) Otolaryngology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575085/
https://www.ncbi.nlm.nih.gov/pubmed/36258884
http://dx.doi.org/10.1002/lio2.882
work_keys_str_mv AT chenyenchun impairedspontaneoussecretionasapotentialfactorinthedevelopmentofsialolithiasisinthesubmandibularglandapreliminarysialoscintigraphicstudy
AT dangluonghuu impairedspontaneoussecretionasapotentialfactorinthedevelopmentofsialolithiasisinthesubmandibularglandapreliminarysialoscintigraphicstudy
AT changweiwen impairedspontaneoussecretionasapotentialfactorinthedevelopmentofsialolithiasisinthesubmandibularglandapreliminarysialoscintigraphicstudy
AT suchinhui impairedspontaneoussecretionasapotentialfactorinthedevelopmentofsialolithiasisinthesubmandibularglandapreliminarysialoscintigraphicstudy
AT hungshihhan impairedspontaneoussecretionasapotentialfactorinthedevelopmentofsialolithiasisinthesubmandibularglandapreliminarysialoscintigraphicstudy