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Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance

Mutations and gene amplifications that confer drug resistance emerge frequently during chemotherapy, but their mechanism and timing are poorly understood. Here, we investigate BRAF(V600E) amplification events that underlie resistance to the MEK inhibitor selumetinib (AZD6244/ARRY-142886) in COLO205...

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Detalles Bibliográficos
Autores principales:	Channathodiyil, Prasanna, May, Kieron, Segonds-Pichon, Anne, Smith, Paul D, Cook, Simon J, Houseley, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575185/ https://www.ncbi.nlm.nih.gov/pubmed/36267209 http://dx.doi.org/10.1093/narcan/zcac032

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