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Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila
BACKGROUND: Aberrant aggregation of α-synuclein (α-syn) is a key pathological feature of Parkinson’s disease (PD), but the precise role of intestinal α-syn in the progression of PD is unclear. In a number of genetic Drosophila models of PD, α-syn was frequently ectopically expressed in the neural sy...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575256/ https://www.ncbi.nlm.nih.gov/pubmed/36253844 http://dx.doi.org/10.1186/s40035-022-00318-w |