Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

BACKGROUND: DNA methylation is an epigenetic mark associated with the repression of gene promoters. Its pattern in the genome is disrupted with age and these changes can be used to statistically predict age with epigenetic clocks. Altered rates of aging inferred from these clocks are observed in hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Higham, Jonathan, Kerr, Lyndsay, Zhang, Qian, Walker, Rosie M., Harris, Sarah E., Howard, David M., Hawkins, Emma L., Sandu, Anca-Larisa, Steele, J. Douglas, Waiter, Gordon D., Murray, Alison D., Evans, Kathryn L., McIntosh, Andrew M., Visscher, Peter M., Deary, Ian J., Cox, Simon R., Sproul, Duncan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575273/
https://www.ncbi.nlm.nih.gov/pubmed/36253871
http://dx.doi.org/10.1186/s13059-022-02787-8

Ejemplares similares

Ejemplares similares