Network toxicology and molecular docking analyses on strychnine indicate CHRM1 is a potential neurotoxic target

BACKGROUND: Improper use of strychnine can cause death. The aim of this study was to identify and evaluate toxic mechanisms of action associated with active compounds in strychnine using a network toxicology approach, and explore potential pathogenic targets. METHODS: In the present study, strychnin...

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Detalles Bibliográficos
Autores principales: Dai, Jialin, Liu, Jiangjin, Zhang, Maoxin, Yu, Yanni, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575290/
https://www.ncbi.nlm.nih.gov/pubmed/36244968
http://dx.doi.org/10.1186/s12906-022-03753-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575290/
https://www.ncbi.nlm.nih.gov/pubmed/36244968
http://dx.doi.org/10.1186/s12906-022-03753-4

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