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Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview

MicroRNA(miRNA)s have been identified as an emerging class for therapeutic interventions mainly due to their extracellularly stable presence in humans and animals and their potential for horizontal transmission and action. However, treating Type 2 diabetes mellitus using this technology has yet been...

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Autores principales: Palihaderu, PADS, Mendis, BILM, Premarathne, JMKJK, Dias, WKRR, Yeap, Swee Keong, Ho, Wan Yong, Dissanayake, AS, Rajapakse, IH, Karunanayake, P, Senarath, U, Satharasinghe, DA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575458/
https://www.ncbi.nlm.nih.gov/pubmed/36262691
http://dx.doi.org/10.1177/25168657221130041
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author Palihaderu, PADS
Mendis, BILM
Premarathne, JMKJK
Dias, WKRR
Yeap, Swee Keong
Ho, Wan Yong
Dissanayake, AS
Rajapakse, IH
Karunanayake, P
Senarath, U
Satharasinghe, DA
author_facet Palihaderu, PADS
Mendis, BILM
Premarathne, JMKJK
Dias, WKRR
Yeap, Swee Keong
Ho, Wan Yong
Dissanayake, AS
Rajapakse, IH
Karunanayake, P
Senarath, U
Satharasinghe, DA
author_sort Palihaderu, PADS
collection PubMed
description MicroRNA(miRNA)s have been identified as an emerging class for therapeutic interventions mainly due to their extracellularly stable presence in humans and animals and their potential for horizontal transmission and action. However, treating Type 2 diabetes mellitus using this technology has yet been in a nascent state. MiRNAs play a significant role in the pathogenesis of Type 2 diabetes mellitus establishing the potential for utilizing miRNA-based therapeutic interventions to treat the disease. Recently, the administration of miRNA mimics or antimiRs in-vivo has resulted in positive modulation of glucose and lipid metabolism. Further, several cell culture-based interventions have suggested beta cell regeneration potential in miRNAs. Nevertheless, few such miRNA-based therapeutic approaches have reached the clinical phase. Therefore, future research contributions would identify the possibility of miRNA therapeutics for tackling T2DM. This article briefly reported recent developments on miRNA-based therapeutics for treating Type 2 Diabetes mellitus, associated implications, gaps, and recommendations for future studies.
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spelling pubmed-95754582022-10-18 Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview Palihaderu, PADS Mendis, BILM Premarathne, JMKJK Dias, WKRR Yeap, Swee Keong Ho, Wan Yong Dissanayake, AS Rajapakse, IH Karunanayake, P Senarath, U Satharasinghe, DA Epigenet Insights The Epigenetics of Inflammation and Metabolic Disorders MicroRNA(miRNA)s have been identified as an emerging class for therapeutic interventions mainly due to their extracellularly stable presence in humans and animals and their potential for horizontal transmission and action. However, treating Type 2 diabetes mellitus using this technology has yet been in a nascent state. MiRNAs play a significant role in the pathogenesis of Type 2 diabetes mellitus establishing the potential for utilizing miRNA-based therapeutic interventions to treat the disease. Recently, the administration of miRNA mimics or antimiRs in-vivo has resulted in positive modulation of glucose and lipid metabolism. Further, several cell culture-based interventions have suggested beta cell regeneration potential in miRNAs. Nevertheless, few such miRNA-based therapeutic approaches have reached the clinical phase. Therefore, future research contributions would identify the possibility of miRNA therapeutics for tackling T2DM. This article briefly reported recent developments on miRNA-based therapeutics for treating Type 2 Diabetes mellitus, associated implications, gaps, and recommendations for future studies. SAGE Publications 2022-10-15 /pmc/articles/PMC9575458/ /pubmed/36262691 http://dx.doi.org/10.1177/25168657221130041 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle The Epigenetics of Inflammation and Metabolic Disorders
Palihaderu, PADS
Mendis, BILM
Premarathne, JMKJK
Dias, WKRR
Yeap, Swee Keong
Ho, Wan Yong
Dissanayake, AS
Rajapakse, IH
Karunanayake, P
Senarath, U
Satharasinghe, DA
Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview
title Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview
title_full Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview
title_fullStr Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview
title_full_unstemmed Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview
title_short Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview
title_sort therapeutic potential of mirnas for type 2 diabetes mellitus: an overview
topic The Epigenetics of Inflammation and Metabolic Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9575458/
https://www.ncbi.nlm.nih.gov/pubmed/36262691
http://dx.doi.org/10.1177/25168657221130041
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